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    Rh7 Rhodopsin 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39389, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rh7provided by FlyBase
    Official Full Name
    Rhodopsin 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0036260
    Locus tag
    Dmel_CG5638
    See related
    AllianceGenome:FB:FBgn0036260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.34; anon-WO0170980.35; CG5638; DMELRH7; Dmel\CG5638; Rh; rh7; RH7
    Summary
    Predicted to enable G protein-coupled photoreceptor activity and peptide binding activity. Involved in G protein-coupled opsin signaling pathway; circadian behavior; and photoperiodism. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Is expressed in adult brain; adult optic lobe; pacemaker neurons; photoreceptor neurons; and retina. Orthologous to human OPN4 (opsin 4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Rh7 in Genome Data Viewer
    Location:
    68F8-69A1; 3-38 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12164205..12175482, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12157305..12168582, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Neurexin IV Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Carbonic anhydrase 2 Neighboring gene Myo-inositol oxygenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rhodopsin 7-The unusual Rhodopsin in Drosophila. Senthilan PR, et al. PeerJ, 2016. PMID 27651995, Free PMC Article
    2. Drosophila melanogaster rhodopsin Rh7 is a UV-to-visible light sensor with an extraordinarily broad absorption spectrum. Sakai K, et al. Sci Rep, 2017 Aug 4. PMID 28779161, Free PMC Article
    3. Circadian photoreceptors are required for light-dependent maintenance of long-term memory in Drosophila. Inami S, et al. Neurosci Res, 2022 Dec. PMID 36096270
    4. Drosophila photoreceptor systems converge in arousal neurons and confer light responsive robustness. Au DD, et al. Front Neurosci, 2023. PMID 37274190, Free PMC Article
    5. Drosophila Rhodopsin 7 can partially replace the structural role of Rhodopsin 1, but not its physiological function. Grebler R, et al. J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2017 Aug. PMID 28500442, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Altered circadian rhythm, sleep, and rhodopsin 7-dependent shade preference during diapause in Drosophila melanogaster.
      Title: Altered circadian rhythm, sleep, and rhodopsin 7-dependent shade preference during diapause in Drosophila melanogaster.
    2. findings show that Rh7 is a promising photopigment that might interact with circadian photoreception of the fruit fly in the DN1a, DN1p, inner R8 photoreceptor cells, and putatively also H-B eyelets and, in this way, modulate activity patterns
      Title: A New Rhodopsin Influences Light-dependent Daily Activity Patterns of Fruit Flies.
    3. The demonstration that Rh7 functions in circadian pacemaker neurons represents, to our knowledge, the first role for an opsin in the central brain.
      Title: A rhodopsin in the brain functions in circadian photoentrainment in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled photoreceptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled opsin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cellular response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in entrainment of circadian clock by photoperiod IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in entrainment of circadian clock by photoperiod IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to photoperiod, blue light IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rhodopsin 7
    Names
    CG5638-PA
    Rh7-PA
    rhodopsin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12164205..12175482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079311.3 → NP_524035.2  rhodopsin 7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524035.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95T73, Q9VTU7
      Related
      FBpp0075752
      Conserved Domains (2) summary
      pfam00001
      Location:133 → 384
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:125 → 247
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTU7 Q9VTU7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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