U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ACSBG1 acyl-CoA synthetase bubblegum family member 1 [ Homo sapiens (human) ]

    Gene ID: 23205, updated on 9-Dec-2024

    Summary

    Official Symbol
    ACSBG1provided by HGNC
    Official Full Name
    acyl-CoA synthetase bubblegum family member 1provided by HGNC
    Primary source
    HGNC:HGNC:29567
    See related
    Ensembl:ENSG00000103740 MIM:614362; AllianceGenome:HGNC:29567
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BG; BG1; BGM; LPD; GR-LACS
    Summary
    The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 8.4), adrenal (RPKM 6.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ACSBG1 in Genome Data Viewer
    Location:
    15q25.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (78167468..78234565, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (76030054..76108241, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (78459810..78526907, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9910 Neighboring gene calcium and integrin binding family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6705 Neighboring gene uncharacterized LOC124903534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6706 Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9911 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78500283-78500794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9913 Neighboring gene DNAJA4 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6709 Neighboring gene uncharacterized LOC105370910 Neighboring gene Sharpr-MPRA regulatory region 12554 Neighboring gene DnaJ heat shock protein family (Hsp40) member A4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ30320, KIAA0631, MGC14352

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables very long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables very long-chain fatty acid-CoA ligase activity TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    long-chain-fatty-acid--CoA ligase ACSBG1
    Names
    bubblegum
    lipidosin
    very long-chain acyl-CoA synthetase
    NP_001186306.1
    NP_055977.3
    XP_011519692.1
    XP_011519693.2
    XP_016877514.1
    XP_047288229.1
    XP_054233533.1
    XP_054233534.1
    XP_054233535.1
    XP_054233536.1
    XP_054233537.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199377.2NP_001186306.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC090260, AK295269, BC009289, DC401742
      UniProtKB/TrEMBL
      B7Z2Y6
      Conserved Domains (2) summary
      cd05933
      Location:125715
      ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
      COG1022
      Location:103718
      FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
    2. NM_015162.5NP_055977.3  long-chain-fatty-acid--CoA ligase ACSBG1 isoform 1

      See identical proteins and their annotated locations for NP_055977.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC090260, AK054882, BC009289, DC401742
      Consensus CDS
      CCDS10298.1
      UniProtKB/Swiss-Prot
      B2RB61, O75126, Q76N27, Q96GR2, Q9HC26
      UniProtKB/TrEMBL
      B3KNS7
      Related
      ENSP00000258873.4, ENST00000258873.9
      Conserved Domains (2) summary
      cd05933
      Location:125719
      ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
      COG1022
      Location:103722
      FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      78167468..78234565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022025.3XP_016877514.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1

      UniProtKB/TrEMBL
      B3KNS7
    2. XM_011521390.4XP_011519692.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X3

      UniProtKB/TrEMBL
      B3KNS7
      Conserved Domains (2) summary
      cd05933
      Location:103697
      ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
      COG1022
      Location:81700
      FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
    3. XM_047432273.1XP_047288229.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X2

      UniProtKB/TrEMBL
      B3KNS7
    4. XM_011521391.3XP_011519693.2  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X4

      UniProtKB/TrEMBL
      B3KNS7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      76030054..76108241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377558.1XP_054233533.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1

      UniProtKB/TrEMBL
      B3KNS7
    2. XM_054377560.1XP_054233535.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X5

      UniProtKB/TrEMBL
      B3KNS7
    3. XM_054377561.1XP_054233536.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X3

      UniProtKB/TrEMBL
      B3KNS7
    4. XM_054377559.1XP_054233534.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X2

      UniProtKB/TrEMBL
      B3KNS7
    5. XM_054377562.1XP_054233537.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X4

      UniProtKB/TrEMBL
      B3KNS7