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    MED25 Mediator complex subunit 25 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42385, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MED25provided by FlyBase
    Official Full Name
    Mediator complex subunit 25provided by FlyBase
    Primary source
    FLYBASE:FBgn0038760
    Locus tag
    Dmel_CG12254
    See related
    AllianceGenome:FB:FBgn0038760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Arc92; CG12254; dARC92; dDrip97; Dmel\CG12254; LD07688; med25; Med25
    Summary
    Predicted to enable transcription coregulator activity. Involved in positive regulation of antibacterial peptide biosynthetic process. Predicted to be located in nucleoplasm. Predicted to be part of mediator complex and transcription regulator complex. Is expressed in organism. Orthologous to human MED25 (mediator complex subunit 25). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MED25 in Genome Data Viewer
    Location:
    92C1-92C1; 3-67 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20008947..20011712)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15834669..15837434)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Heparan sulfate 6-O-sulfotransferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila heparan sulfate 6-O-sulfotransferase (dHS6ST) gene. Structure, expression, and function in the formation of the tracheal system. Kamimura K, et al. J Biol Chem, 2001 May 18. PMID 11278892
    2. Transcriptional cofactors display specificity for distinct types of core promoters. Haberle V, et al. Nature, 2019 Jun. PMID 31092928, Free PMC Article
    3. Transcription regulation and animal diversity. Levine M, et al. Nature, 2003 Jul 10. PMID 12853946
    4. RNA interference screen to identify genes required for Drosophila embryonic nervous system development. Koizumi K, et al. Proc Natl Acad Sci U S A, 2007 Mar 27. PMID 17376868, Free PMC Article
    5. A cis-regulatory-directed pipeline for the identification of genes involved in cardiac development and disease. Nim HT, et al. Genome Biol, 2021 Dec 15. PMID 34906219, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transcription coregulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of antibacterial peptide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mediator complex subunit 25
    Names
    CG12254-PA
    MED25-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20008947..20011712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142597.4 → NP_650854.1  mediator complex subunit 25 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650854.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VDR1
      Related
      FBpp0083234
      Conserved Domains (2) summary
      pfam11232
      Location:524 → 671
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11265
      Location:4 → 218
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDR1.1 Q9VDR1

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