PIG-V Phosphatidylinositol glycan anchor biosynthesis class V [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PIG-Vprovided by FlyBase
Official Full Name: Phosphatidylinositol glycan anchor biosynthesis class Vprovided by FlyBase
Primary source: FLYBASE:FBgn0265174
Locus tag: Dmel_CG44239
See related: AllianceGenome:FB:FBgn0265174
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG44239; CG6657; Dmel\CG44239; gpi-mt2; PIGV
Summary: Predicted to enable alpha-1,6-mannosyltransferase activity. Involved in GPI anchor biosynthetic process and rhabdomere membrane biogenesis. Predicted to be part of mannosyltransferase complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 1. Orthologous to human PIGV (phosphatidylinositol glycan anchor biosynthesis class V). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16955458..16957308)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12842963..12844813)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables alpha-1,6-mannosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables alpha-1,6-mannosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables glycolipid mannosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mannosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in GPI anchor biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GPI anchor biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in GPI anchor biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in rhabdomere membrane biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of mannosyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info

Names: CG44239-PA; CG44239-PB; CG44239-PC; GPI mannosyltransferase II; PIG-V-PA; PIG-V-PB; PIG-V-PC; phosphatidylinositol glycan anchor biosynthesis, class V; phosphatidylinositol glycan anchor biosynthesis, class V ortholog

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The following sections contain reference sequences that belong to a specific genome build. Explain