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    Bmp6 bone morphogenetic protein 6 [ Mus musculus (house mouse) ]

    Gene ID: 12161, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bmp6provided by MGI
    Official Full Name
    bone morphogenetic protein 6provided by MGI
    Primary source
    MGI:MGI:88182
    See related
    Ensembl:ENSMUSG00000039004 AllianceGenome:MGI:88182
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vgr1; D13Wsu115e
    Summary
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Mice lacking this gene exhibit delayed ossification of the sternum, iron overload, and reduced fertility in females. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in lung adult (RPKM 52.0), kidney adult (RPKM 13.2) and 10 other tissues See more
    Orthologs
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    Genomic context

    See Bmp6 in Genome Data Viewer
    Location:
    13 A3.3; 13 18.15 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (38529098..38684283)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (38345716..38500314)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 47978 Neighboring gene predicted gene, 47990 Neighboring gene RIKEN cDNA 4930579J19 gene Neighboring gene STARR-seq mESC enhancer starr_34248 Neighboring gene thioredoxin domain containing 5 Neighboring gene predicted gene, 31834 Neighboring gene predicted gene, 40922

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables BMP receptor binding PubMed 
    enables cytokine activity  
    enables cytokine activity  
    enables growth factor activity  
    enables growth factor activity  
    enables protein binding PubMed 
    enables protein heterodimerization activity PubMed 
    Items 1 - 25 of 59
    Process Evidence Code Pubs
    involved_in BMP signaling pathway  
    acts_upstream_of_or_within BMP signaling pathway PubMed 
    involved_in BMP signaling pathway  
    involved_in bone development  
    involved_in cartilage development  
    involved_in cellular response to BMP stimulus  
    involved_in cellular response to iron ion PubMed 
    involved_in cellular response to mechanical stimulus  
    acts_upstream_of_or_within endochondral ossification PubMed 
    involved_in eye development PubMed 
    involved_in immune response  
    involved_in immune response  
    involved_in inflammatory response PubMed 
    acts_upstream_of_or_within intracellular iron ion homeostasis PubMed 
    involved_in intracellular iron ion homeostasis PubMed 
    involved_in kidney development PubMed 
    acts_upstream_of_or_within male genitalia development PubMed 
    involved_in multicellular organismal-level iron ion homeostasis PubMed 
    involved_in multicellular organismal-level iron ion homeostasis  
    involved_in multicellular organismal-level iron ion homeostasis  
    involved_in negative regulation of adherens junction organization  
    involved_in negative regulation of adherens junction organization  
    involved_in negative regulation of cell-cell adhesion mediated by cadherin  
    involved_in negative regulation of cell-cell adhesion mediated by cadherin  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within neuron differentiation PubMed 
    involved_in ossification  
    acts_upstream_of_or_within osteoblast differentiation PubMed 
    involved_in positive regulation of SMAD protein signal transduction PubMed 
    involved_in positive regulation of SMAD protein signal transduction  
    involved_in positive regulation of aldosterone biosynthetic process  
    involved_in positive regulation of aldosterone biosynthetic process  
    involved_in positive regulation of aldosterone secretion  
    involved_in positive regulation of aldosterone secretion  
    involved_in positive regulation of bone mineralization  
    involved_in positive regulation of bone mineralization  
    involved_in positive regulation of chondrocyte differentiation  
    involved_in positive regulation of chondrocyte differentiation  
    involved_in positive regulation of endothelial cell differentiation PubMed 
    involved_in positive regulation of endothelial cell proliferation PubMed 
    involved_in positive regulation of epithelial cell proliferation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of lipopolysaccharide-mediated signaling pathway PubMed 
    acts_upstream_of_or_within positive regulation of neuron differentiation PubMed 
    involved_in positive regulation of osteoblast differentiation  
    involved_in positive regulation of osteoblast differentiation  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of vascular permeability  
    involved_in positive regulation of vascular permeability  
    involved_in response to activity  
    involved_in response to glucocorticoid  
    involved_in response to magnesium ion  
    involved_in response to retinoic acid  
    involved_in type B pancreatic cell development  
    involved_in type B pancreatic cell development  
    Items 1 - 25 of 59
    Component Evidence Code Pubs
    located_in extracellular space PubMed 
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  
    located_in vesicle  
    located_in vesicle  

    General protein information

    Preferred Names
    bone morphogenetic protein 6
    Names
    VG-1-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007556.4NP_031582.1  bone morphogenetic protein 6 preproprotein

      See identical proteins and their annotated locations for NP_031582.1

      Status: VALIDATED

      Source sequence(s)
      AC124549, AC154747
      Consensus CDS
      CCDS26462.1
      UniProtKB/Swiss-Prot
      B2RRV6, P20722
      UniProtKB/TrEMBL
      Q3UXB2
      Related
      ENSMUSP00000126999.2, ENSMUST00000171970.3
      Conserved Domains (2) summary
      smart00204
      Location:409510
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:58359
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      38529098..38684283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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