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    Lfg Lifeguard [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36418, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lfgprovided by FlyBase
    Official Full Name
    Lifeguardprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025692
    Locus tag
    Dmel_CG3814
    See related
    AllianceGenome:FB:FBgn0025692
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:CK02213; CG3814; CK02213; Dmel\CG3814; LFG
    Summary
    Predicted to enable calcium channel activity. Involved in negative regulation of apoptotic process. Predicted to be active in Golgi apparatus and organelle membrane. Is expressed in embryonic midgut chamber and embryonic/larval midgut. Orthologous to human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lfg in Genome Data Viewer
    Location:
    49D6-49D6; 2-67 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12875164..12876966, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8762669..8764471, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene bicaudal Neighboring gene antisense RNA:CR43469 Neighboring gene Beta-alanine transporter Neighboring gene antisense RNA:CR43468 Neighboring gene Aspartyl-tRNA synthetase Neighboring gene N-methyl-D-aspartate receptor-associated protein Neighboring gene antisense RNA:CR45141

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Knockdown of the putative Lifeguard homologue CG3814 in neurons of Drosophila melanogaster. M'Angale PG, et al. Genet Mol Res, 2016 Dec 19. PMID 28002605
    2. The Evolutionary Conserved Transmembrane BAX Inhibitor Motif (TMBIM) Containing Protein Family Members 5 and 6 Are Essential for the Development and Survival of Drosophila melanogaster. Zhang L, et al. Front Cell Dev Biol, 2021. PMID 34540824, Free PMC Article
    3. TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Rojas-Rivera D, et al. Cell Death Differ, 2012 Jun. PMID 22240901, Free PMC Article
    4. Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging. Kuintzle RC, et al. Nat Commun, 2017 Feb 21. PMID 28221375, Free PMC Article
    5. Furthering pharmacological and physiological assessment of the glutamatergic receptors at the Drosophila neuromuscular junction. Lee JY, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2009 Nov. PMID 19695344

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in organelle membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lifeguard
    Names
    CG3814-PA
    CG3814-PB
    CG3814-PC
    CG3814-PD
    Lfg-PA
    Lfg-PB
    Lfg-PC
    Lfg-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12875164..12876966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165955.3 → NP_725236.1  lifeguard, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725236.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T8W2
      Related
      FBpp0086926
      Conserved Domains (1) summary
      cd10428
      Location:23 → 240
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    2. NM_136980.4 → NP_610824.1  lifeguard, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610824.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWP0
      Related
      FBpp0086927
      Conserved Domains (1) summary
      cd10428
      Location:18 → 235
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    3. NM_001273999.1 → NP_001260928.1  lifeguard, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260928.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWP0
      Conserved Domains (1) summary
      cd10428
      Location:18 → 235
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    4. NM_001273998.1 → NP_001260927.1  lifeguard, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260927.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEN6
      Conserved Domains (1) summary
      cd10428
      Location:1 → 199
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEN6 A0A0B4KEN6
    Q6AWP0 Q6AWP0
    Q8T8W2 Q8T8W2

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