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    ODA-Dnal1 Outer dynein arm dynein axonemal light chain 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35962, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ODA-Dnal1provided by FlyBase
    Official Full Name
    Outer dynein arm dynein axonemal light chain 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033408
    Locus tag
    Dmel_CG8800
    See related
    AllianceGenome:FB:FBgn0033408
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8800; Dmel\CG8800
    Summary
    Predicted to enable alpha-tubulin binding activity and dynein heavy chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be part of outer dynein arm. Predicted to be active in cytoplasm. Is expressed in chordotonal neurons and spermatogonium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 16. Orthologous to human DNAL1 (dynein axonemal light chain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ODA-Dnal1 in Genome Data Viewer
    Location:
    45D1-45D2; 2-60 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9395330..9396206, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5282835..5283711, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene lethal (2) 03659 Neighboring gene lethal (2) k10201 Neighboring gene uncharacterized protein Neighboring gene Novel nucleolar protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The dynamics of protein localisation to restricted zones within Drosophila mechanosensory cilia. Xiang W, et al. Sci Rep, 2022 Aug 3. PMID 35922464, Free PMC Article
    2. Forkhead transcription factor Fd3F cooperates with Rfx to regulate a gene expression program for mechanosensory cilia specialization. Newton FG, et al. Dev Cell, 2012 Jun 12. PMID 22698283, Free PMC Article
    3. Dyneins across eukaryotes: a comparative genomic analysis. Wickstead B, et al. Traffic, 2007 Dec. PMID 17897317, Free PMC Article
    4. Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Avidor-Reiss T, et al. Cell, 2004 May 14. PMID 15137945
    5. Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies. Zur Lage P, et al. Front Genet, 2019. PMID 30774648, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of outer dynein arm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    outer dynein arm dynein axonemal light chain 1
    Names
    CG8800-PA
    ODA light chain
    ODA-Dnal1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9395330..9396206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136639.3 → NP_610483.1  outer dynein arm dynein axonemal light chain 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610483.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7U2
      Related
      FBpp0087638
      Conserved Domains (2) summary
      sd00033
      Location:50 → 71
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:37 → 180
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7U2 A1Z7U2

    Gene LinkOut

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