Tpi Triose phosphate isomerase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tpiprovided by FlyBase
Official Full Name: Triose phosphate isomeraseprovided by FlyBase
Primary source: FLYBASE:FBgn0086355
Locus tag: Dmel_CG2171
See related: AllianceGenome:FB:FBgn0086355
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2171; Dmel\CG2171; ND14; sgk; tpi; TPI; TPIS; wstd
Summary: Enables protein homodimerization activity and triose-phosphate isomerase activity. Involved in several processes, including canonical glycolysis; determination of adult lifespan; and glucose homeostasis. Located in M band and Z disc. Is expressed in several structures, including adult head; adult heart; larval muscle system; muscle cell; and spermatozoon. Used to study neurodegenerative disease and triosephosphate isomerase deficiency. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Orthologous to human TPI1 (triosephosphate isomerase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 99D8-99D8; 3-100 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (30132981..30134599, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25958703..25960321, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our findings are the first to identify, to our knowledge, a functional synaptic defect in TPI deficiency derived from molecular changes in the TPI dimer interface.
Title: Structural and Genetic Studies Demonstrate Neurologic Dysfunction in Triosephosphate Isomerase Deficiency Is Associated with Impaired Synaptic Vesicle Dynamics.
TPI sugarkill can be genetically complemented by TPI encoding a catalytically inactive enzyme.
Title: Evidence of a triosephosphate isomerase non-catalytic function crucial to behavior and longevity.
Mutation of wasted away, a recessive, hypomorphic mutation of triosephosphate isomerase (Tpi), highlights the essential protective role of triosephosphate isomerase.
Title: wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1747 (e-PCR)
- UniSTS:56748

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables triose-phosphate isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables triose-phosphate isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables triose-phosphate isomerase activity	IEA Inferred from Electronic Annotation more info
enables triose-phosphate isomerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables triose-phosphate isomerase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in canonical glycolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glyceraldehyde-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glyceraldehyde-3-phosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glyceraldehyde-3-phosphate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycerol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in M band	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: triose phosphate isomerase

Names: CG2171-PA; CG2171-PB; CG2171-PC; Tpi-PA; Tpi-PB; Tpi-PC; neurodegeneration 14; sugarkill; triosephosphate isomerase; wasted away

NP_788764.1

EC 5.3.1.1

NP_788765.1

EC 5.3.1.1

NP_788766.1

EC 5.3.1.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

30132981..30134599 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_176587.2 → NP_788764.1 triose phosphate isomerase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788764.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29613

Related

FBpp0084948

Conserved Domains (1) summary

PTZ00333
Location:102 → 346

PTZ00333; triosephosphate isomerase; Provisional
NM_176588.2 → NP_788765.1 triose phosphate isomerase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788765.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76995, P29613, Q0KHY9, Q6NLI5, Q7JNU4, Q8IMJ1, Q9TY56

Related

FBpp0084949

Conserved Domains (1) summary

PTZ00333
Location:1 → 245

PTZ00333; triosephosphate isomerase; Provisional
NM_176589.2 → NP_788766.1 triose phosphate isomerase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788766.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76995, P29613, Q0KHY9, Q6NLI5, Q7JNU4, Q8IMJ1, Q9TY56

Related

FBpp0084950

Conserved Domains (1) summary

PTZ00333
Location:1 → 245

PTZ00333; triosephosphate isomerase; Provisional