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    Jon99Cii Jonah 99Cii [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43544, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jon99Ciiprovided by FlyBase
    Official Full Name
    Jonah 99Ciiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003356
    Locus tag
    Dmel_CG31034
    See related
    AllianceGenome:FB:FBgn0003356
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    99Calpha; CG31034; CG7877; Dmel\CG31034; Jon99B; Jon99C; Jon99C1; Jon99C2; Jon99Calpha; Jon99Calphai; Jon99Cbeta; Jon99Cbetaii; Jon99Ciii; JonC; Ser1; SER1; Ser5; Ser99Da; Serl; SP122
    Summary
    Enables serine hydrolase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Jon99Cii in Genome Data Viewer
    Location:
    99C7-99C7; 3-99 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29923754..29924615, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25749476..25750337, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transient receptor potential Neighboring gene Jonah 99Ciii Neighboring gene Jonah 99Ci Neighboring gene uncharacterized protein Neighboring gene alpha-Mannosidase class I c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Levels of RNA from a family of putative serine protease genes are reduced in Drosophila melanogaster dunce mutants and are regulated by cyclic AMP. Yun Y, et al. Mol Cell Biol, 1989 Feb. PMID 2469005, Free PMC Article
    2. Isolation and cloning of Ser4, a gene encoding a trypsin-like serine protease in Drosophila melanogaster. Ahrens JE, et al. Biochim Biophys Acta, 1998 Jan 21. PMID 9473638
    3. Induction of a putative serine protease transcript in immune challenged Drosophila. Coustau C, et al. Dev Comp Immunol, 1996 Jul-Aug. PMID 8915628
    4. The detection of Jonah gene transcripts in Drosophila by in situ hybridization. Akam ME, et al. EMBO J, 1985 Jan. PMID 2410252, Free PMC Article
    5. Developmental and functional analysis of Jonah gene expression. Carlson JR, et al. Dev Biol, 1985 Apr. PMID 2416611

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    jonah 99Cii
    Names
    CG31034-PA
    Jon99Cii-PA
    jonah 99C alpha
    jonah 99C beta
    serine protease 1
    serine protease 5
    NP_524554.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29923754..29924615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079830.4 → NP_524554.1  jonah 99Cii [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524554.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0HKF7, C0HKF8, P17205, Q23988, Q9VAD9, Q9VAE0
      UniProtKB/TrEMBL
      A0A0B4LHX9, Q5BI60
      Related
      FBpp0084878
      Conserved Domains (1) summary
      cd00190
      Location:36 → 260
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0HKF7.1 C0HKF7
    C0HKF8.1 C0HKF8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials