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    Acsbg1 acyl-CoA synthetase bubblegum family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 94180, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acsbg1provided by MGI
    Official Full Name
    acyl-CoA synthetase bubblegum family member 1provided by MGI
    Primary source
    MGI:MGI:2385656
    See related
    Ensembl:ENSMUSG00000032281 AllianceGenome:MGI:2385656
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BG1; Bgm; Lpd; GR-LACS; E230019G03Rik
    Summary
    Predicted to enable long-chain fatty acid-CoA ligase activity and very long-chain fatty acid-CoA ligase activity. Acts upstream of or within response to glucocorticoid. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; face; genitourinary system; integumental system; and skeleton. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Orthologous to human ACSBG1 (acyl-CoA synthetase bubblegum family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 280.6), adrenal adult (RPKM 69.5) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acsbg1 in Genome Data Viewer
    Location:
    9 A5.3; 9 29.7 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (54512163..54569169, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (54604886..54661885, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 7 Neighboring gene calcium and integrin binding family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E888 Neighboring gene STARR-seq mESC enhancer starr_24171 Neighboring gene isocitrate dehydrogenase 3 (NAD+) alpha Neighboring gene predicted gene, 51677 Neighboring gene predicted gene, 39341 Neighboring gene 5730494N06Rik pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The gonadotropin-regulated long-chain acyl CoA synthetase gene: a novel downstream Sp1/Sp3 binding element critical for transcriptional promoter activity. Sheng Y, et al. Gene, 2005 Oct 24. PMID 16125341
    2. Role of ACSBG1 in Brain Lipid Metabolism and X-Linked Adrenoleukodystrophy Pathogenesis: Insights from a Knockout Mouse Model. Ye X, et al. Cells, 2024 Oct 12. PMID 39451204, Free PMC Article
    3. Lessons from the gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) null mouse model: a role in steroidogenesis, but not result in X-ALD phenotype. Sheng Y, et al. J Steroid Biochem Mol Biol, 2009 Mar. PMID 19167491
    4. Cloning and characterization of a hormonally regulated rat long chain acyl-CoA synthetase. Tang PZ, et al. Proc Natl Acad Sci U S A, 2001 Jun 5. PMID 11381125, Free PMC Article
    5. The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation. Pei Z, et al. J Biol Chem, 2003 Nov 21. PMID 12975357

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue Treg cell homeostasis.
      Title: Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue T(reg) cell homeostasis.
    2. These data suggest that lipidosin was involved in fatty acid metabolism during reconstruction of the myelin sheath.
      Title: Expression of an acyl-CoA synthetase, lipidosin, in astrocytes of the murine brain and its up-regulation during remyelination following cuprizone-induced demyelination.
    3. Expression pattern and localization of bubblegum to microsomes.
      Title: Murine bubblegum orthologue is a microsomal very long-chain acyl-CoA synthetase.
    4. in neurons, mBG1-activated long-chain fatty acids are directed toward mitochondrial degradation
      Title: The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0631

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables very long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables very long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within response to glucocorticoid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in very long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very long-chain fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    long-chain-fatty-acid--CoA ligase ACSBG1
    Names
    bubblegum
    gonadotropin-regulated long chain acyl CoA synthetase
    lipidosin
    lipidosis-related protein lipidosin
    lipodisin
    NP_444408.1
    XP_006511651.1
    XP_030100613.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053178.2 → NP_444408.1  long-chain-fatty-acid--CoA ligase ACSBG1

      See identical proteins and their annotated locations for NP_444408.1

      Status: VALIDATED

      Source sequence(s)
      AC157591
      Consensus CDS
      CCDS23192.1
      UniProtKB/Swiss-Prot
      Q6ZQ79, Q99PU5
      Related
      ENSMUSP00000034822.6, ENSMUST00000034822.12
      Conserved Domains (2) summary
      cd05933
      Location:122 → 716
      ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
      COG1022
      Location:100 → 719
      FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      54512163..54569169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244753.2 → XP_030100613.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1

      Conserved Domains (1) summary
      cd05933
      Location:155 → 749
      ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)

    2. XM_006511588.4 → XP_006511651.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X2

      Conserved Domains (1) summary
      cd05933
      Location:131 → 725
      ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PU5.1 GenPept UniProtKB/Swiss-Prot:Q99PU5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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