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    Frs3 fibroblast growth factor receptor substrate 3 [ Mus musculus (house mouse) ]

    Gene ID: 107971, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Frs3provided by MGI
    Official Full Name
    fibroblast growth factor receptor substrate 3provided by MGI
    Primary source
    MGI:MGI:2135965
    See related
    Ensembl:ENSMUSG00000023266 AllianceGenome:MGI:2135965
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Snt2; Frs2beta; 4930417B13Rik
    Summary
    Predicted to enable fibroblast growth factor receptor binding activity; identical protein binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; gut; immune system; lung; and metanephros. Orthologous to human FRS3 (fibroblast growth factor receptor substrate 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 16.9), CNS E18 (RPKM 9.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Frs3 in Genome Data Viewer
    Location:
    17 C; 17 23.88 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47998532..48015211)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47687607..47704286)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20517 Neighboring gene mediator complex subunit 20 Neighboring gene Kpna2 retrotransposed pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10959 Neighboring gene ubiquitin specific peptidase 49 Neighboring gene STARR-positive B cell enhancer ABC_E4218 Neighboring gene prickle planar cell polarity protein 4 Neighboring gene translocase of outer mitochondrial membrane 6, opposite strand Neighboring gene translocase of outer mitochondrial membrane 6 Neighboring gene STARR-seq mESC enhancer starr_42721 Neighboring gene fibroblast growth factor receptor substrate 3, opposite strand Neighboring gene STARR-seq mESC enhancer starr_42724 Neighboring gene predicted gene, 46579 Neighboring gene progastricsin (pepsinogen C)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis. Takeuchi Y, et al. Proc Natl Acad Sci U S A, 2021 Oct 26. PMID 34663724, Free PMC Article
    2. Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis. Nandi S, et al. Neuroscience, 2018 Jan 15. PMID 29155277, Free PMC Article
    3. Genomic organization and comparative sequence analysis of the mouse and human FRS2, FRS3 genes. Zhou L, et al. Mol Biol Rep, 2003 Mar. PMID 12688531
    4. Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformation. Chikamori M, et al. Oncogene, 2007 May 3. PMID 17086210
    5. The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins. Ranzi V, et al. Endocrinology, 2003 Mar. PMID 12586769

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The membrane-linked adaptor FRS2beta fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis.
      Title: The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis.
    2. FRS2 and FRS3, are together required for postnatal brain development. In the hippocampus, FRS2&3 promote dentate gyrus morphogenesis and dentate granule cell (DGC) maturation during developmental neurogenesis. Frs2,3-double mutants have reduced numbers of dendritic branches and spines in DGCs. Double-mutant mice exhibit fewer excitatory synaptic inputs onto DGCs.
      Title: Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis.
    3. Analysis of a mutant Fgfr1 allele, unable to bind to the adaptor protein, Frs2/3, indicates that Sox2 maintenance can be
      Title: FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation.
    4. Prominent expression of Frs2beta protein in neural cells and its association with intracellular vesicles is reported.
      Title: Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles.
    5. The results showed that the interaction of full-length FRS2beta with FGFR1 was not enhanced by activation of the receptor kinase.
      Title: Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor.
    6. Some essential functions of Fgfr1 are mediated by Frs-independent signaling.
      Title: Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development.
    7. data indicate that the fibroblast growth factor receptor substrate 2 and fibroblast growth factor receptor substrate 3 adapters may have a role in thyroid carcinogenesis triggered by TRK oncogenes
      Title: The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins.
    8. ULK2, by interaction with FRS2/3 and inhibition of SynGAP, functions to negatively regulate tyrosyl phosphorylation of signaling proteins downstream of FGFR1.
      Title: UNC-51-like kinase regulation of fibroblast growth factor receptor substrate 2/3.
    9. SNT family proteins may play significant roles in cellular transformation triggered by NPM-ALK.
      Title: Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC25496

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fibroblast growth factor receptor substrate 3
    Names
    FGFR substrate 3
    FRS2-beta
    suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419207.1 → NP_001406136.1  fibroblast growth factor receptor substrate 3

      Status: VALIDATED

      Source sequence(s)
      AC124830, AC139214
      UniProtKB/Swiss-Prot
      Q91WJ0

    2. NM_001419208.1 → NP_001406137.1  fibroblast growth factor receptor substrate 3

      Status: VALIDATED

      Source sequence(s)
      AC124830, AC139214
      UniProtKB/Swiss-Prot
      Q91WJ0

    3. NM_144939.3 → NP_659188.1  fibroblast growth factor receptor substrate 3

      See identical proteins and their annotated locations for NP_659188.1

      Status: VALIDATED

      Source sequence(s)
      AC124830, AC139214
      Consensus CDS
      CCDS28854.1
      UniProtKB/Swiss-Prot
      Q91WJ0
      Related
      ENSMUSP00000108921.2, ENSMUST00000113296.8
      Conserved Domains (1) summary
      cd01202
      Location:15 → 106
      PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      47998532..48015211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523469.4 → XP_006523532.1  fibroblast growth factor receptor substrate 3 isoform X1

      See identical proteins and their annotated locations for XP_006523532.1

      UniProtKB/Swiss-Prot
      Q91WJ0
      Conserved Domains (1) summary
      cd01202
      Location:15 → 106
      PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

    2. XM_036160258.1 → XP_036016151.1  fibroblast growth factor receptor substrate 3 isoform X2

      Conserved Domains (1) summary
      cl17171
      Location:17 → 38
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WJ0.3 GenPept UniProtKB/Swiss-Prot:Q91WJ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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