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    Naa30A N(alpha)-acetyltransferase 30 A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31079, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Naa30Aprovided by FlyBase
    Official Full Name
    N(alpha)-acetyltransferase 30 Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024362
    Locus tag
    Dmel_CG11412
    See related
    AllianceGenome:FB:FBgn0024362
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg11412; CG11412; DmAAF45606; Dmel\CG11412; EG:8D8.6; Naa30; NAA30
    Summary
    Predicted to enable peptide alpha-N-acetyltransferase activity. Predicted to be involved in N-terminal peptidyl-methionine acetylation. Part of NatC complex. Is expressed in organism. Orthologous to human NAA30 (N-alpha-acetyltransferase 30, NatC catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Naa30A in Genome Data Viewer
    Location:
    1F3-1F4; 1-0.1 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1342106..1344770)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1236139..1238803)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene female sterile (1) Nasrat Neighboring gene uncharacterized protein Neighboring gene mitochondrial poly(A) polymerase Neighboring gene Tetraspanin 2A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins. Polevoda B, et al. J Mol Biol, 2003 Jan 24. PMID 12507466
    2. N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity. Varland S, et al. Nat Commun, 2023 Oct 27. PMID 37891180, Free PMC Article
    3. Drosophila Embryos as a Model for Wound-Induced Transcriptional Dynamics: Genetic Strategies to Achieve a Localized Wound Response. Juarez MT. Adv Wound Care (New Rochelle), 2016 Jun 1. PMID 27274436, Free PMC Article
    4. Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development. Mok JW, et al. Proc Natl Acad Sci U S A, 2021 Jan 26. PMID 33479178, Free PMC Article
    5. Duox, Flotillin-2, and Src42A are required to activate or delimit the spread of the transcriptional response to epidermal wounds in Drosophila. Juarez MT, et al. PLoS Genet, 2011 Dec. PMID 22242003, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peptide alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-methionine acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NatC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NatC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    N(alpha)-acetyltransferase 30 A
    Names
    CG11412-PA
    CG11412-PD
    N(alpha)-acetyltransferase 30
    Naa30A-PA
    Naa30A-PD
    NP_001259128.1
    NP_726727.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1342106..1344770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166878.3 → NP_726727.1  N(alpha)-acetyltransferase 30 A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726727.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46309, Q95RC0, Q9W5A3
      UniProtKB/TrEMBL
      E8NH31
      Related
      FBpp0070202
      Conserved Domains (2) summary
      TIGR01575
      Location:242 → 370
      rimI; ribosomal-protein-alanine acetyltransferase
      pfam00583
      Location:276 → 354
      Acetyltransf_1; Acetyltransferase (GNAT) family

    2. NM_001272199.2 → NP_001259128.1  N(alpha)-acetyltransferase 30 A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259128.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH31, M9PGL2
      Conserved Domains (2) summary
      TIGR01575
      Location:223 → 351
      rimI; ribosomal-protein-alanine acetyltransferase
      pfam00583
      Location:257 → 335
      Acetyltransf_1; Acetyltransferase (GNAT) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGL2 M9PGL2
    Q95RC0.1 Q95RC0

    Gene LinkOut

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