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    nsl1 non-specific lethal 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41911, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nsl1provided by FlyBase
    Official Full Name
    non-specific lethal 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0262527
    Locus tag
    Dmel_CG4699
    See related
    AllianceGenome:FB:FBgn0262527
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4699; Dmel\CG4699; E(nos); l(3)06536; l(3)S009413; Nsl1; NSL1; wah
    Summary
    Enables chromatin binding activity and histone acetyltransferase binding activity. Involved in several processes, including germ-line stem cell population maintenance; germarium-derived female germ-line cyst formation; and larval somatic muscle development. Located in cytoplasm; nucleus; and polytene chromosome interband. Part of NSL complex. Is expressed in several structures, including adult central complex; brain; fat body; follicle cell; and germline cell. Used to study Koolen de Vries syndrome and intellectual disability. Human ortholog(s) of this gene implicated in Koolen de Vries syndrome. Orthologous to several human genes including KANSL1 (KAT8 regulatory NSL complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nsl1 in Genome Data Viewer
    Location:
    89A5-89A5; 3-58 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15793782..15802102)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11619504..11627824)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Uroporphyrinogen III synthase 2 Neighboring gene crossover suppressor on 3 of Gowen Neighboring gene Acylphosphatase 2 Neighboring gene antisense RNA:CR45891 Neighboring gene alpha-Mannosidase class II b Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45211

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the chromatin modifier gene KANSL1 cause the 17q21.31 microdeletion syndrome. Koolen DA, et al. Nat Genet, 2012 Apr 29. PMID 22544363
    2. Tumor suppressor roles of CENP-E and Nsl1 in Drosophila epithelial tissues. Clemente-Ruiz M, et al. Cell Cycle, 2014. PMID 24626182, Free PMC Article
    3. Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation. Gaub A, et al. Nat Commun, 2020 May 7. PMID 32382029, Free PMC Article
    4. Polyglutamine genes interact to modulate the severity and progression of neurodegeneration in Drosophila. Lessing D, et al. PLoS Biol, 2008 Feb. PMID 18271626, Free PMC Article
    5. c(3)G encodes a Drosophila synaptonemal complex protein. Page SL, et al. Genes Dev, 2001 Dec 1. PMID 11731477, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone acetyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in germ-line stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in germarium-derived female germ-line cyst formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in larval somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NSL complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome interband IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    non-specific lethal 1
    Names
    CG4699-PD
    CG4699-PE
    CG4699-PF
    CG4699-PH
    CG4699-PI
    CG4699-PJ
    CG4699-PK
    CG4699-PL
    CG4699-PM
    CG4699-PN
    CG4699-PO
    CG4699-PP
    lethal (3) 06536
    nonspecific lethal 1
    nsl1-PD
    nsl1-PE
    nsl1-PF
    nsl1-PH
    nsl1-PI
    nsl1-PJ
    nsl1-PK
    nsl1-PL
    nsl1-PM
    nsl1-PN
    nsl1-PO
    nsl1-PP
    waharan

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15793782..15802102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275684.1 → NP_001262613.1  non-specific lethal 1, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262613.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJH7, E1JIM0
      Conserved Domains (1) summary
      pfam15275
      Location:1229 → 1304
      PEHE; PEHE domain

    2. NM_001170151.3 → NP_001163622.1  non-specific lethal 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163622.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJH7, E1JIM0
      Conserved Domains (1) summary
      pfam15275
      Location:1229 → 1304
      PEHE; PEHE domain

    3. NM_001170152.2 → NP_001163623.1  non-specific lethal 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163623.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2Z1, B5RJH7
      Conserved Domains (1) summary
      pfam15275
      Location:1230 → 1305
      PEHE; PEHE domain

    4. NM_001260197.2 → NP_001247126.1  non-specific lethal 1, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247126.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K690, B5RJH7
      Conserved Domains (1) summary
      pfam15275
      Location:1231 → 1306
      PEHE; PEHE domain

    5. NM_142235.4 → NP_650492.2  non-specific lethal 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650492.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJH7, Q0KI68
      Conserved Domains (1) summary
      pfam15275
      Location:1228 → 1303
      PEHE; PEHE domain

    6. NM_001170153.3 → NP_001163624.1  non-specific lethal 1, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163624.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7VEK2, E1JIM1
      Conserved Domains (1) summary
      PRK08581
      Location:100 → 323
      PRK08581; N-acetylmuramoyl-L-alanine amidase; Validated

    7. NM_001260195.2 → NP_001247124.1  non-specific lethal 1, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247124.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6Z4, B7VEK2
      Conserved Domains (1) summary
      PRK08581
      Location:100 → 323
      PRK08581; N-acetylmuramoyl-L-alanine amidase; Validated

    8. NM_169673.3 → NP_732070.2  non-specific lethal 1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732070.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2Z1, B5RJH7
      Conserved Domains (1) summary
      pfam15275
      Location:1230 → 1305
      PEHE; PEHE domain

    9. NM_169672.4 → NP_732069.3  non-specific lethal 1, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732069.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJH7, E2QD16
      Conserved Domains (1) summary
      pfam15275
      Location:1250 → 1325
      PEHE; PEHE domain

    10. NM_001260194.2 → NP_001247123.1  non-specific lethal 1, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247123.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6I8, B7VEK2
      Conserved Domains (1) summary
      PRK08581
      Location:100 → 323
      PRK08581; N-acetylmuramoyl-L-alanine amidase; Validated

    11. NM_001260196.2 → NP_001247125.1  non-specific lethal 1, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247125.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K663, B5RJH7
      Conserved Domains (1) summary
      pfam15275
      Location:1249 → 1324
      PEHE; PEHE domain

    12. NM_001170150.3 → NP_001163621.1  non-specific lethal 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163621.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2Z1, B5RJH7
      Conserved Domains (1) summary
      pfam15275
      Location:1230 → 1305
      PEHE; PEHE domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K663 A0A0B4K663
    A0A0B4K690 A0A0B4K690
    A0A0B4K6I8 A0A0B4K6I8
    A0A0B4K6Z4 A0A0B4K6Z4
    A4V2Z1 A4V2Z1
    E1JIM0 E1JIM0
    E1JIM1 E1JIM1
    E2QD16 E2QD16
    Q0KI68 Q0KI68

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