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    Tmem260 transmembrane protein 260 [ Mus musculus (house mouse) ]

    Gene ID: 218989, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem260provided by MGI
    Official Full Name
    transmembrane protein 260provided by MGI
    Primary source
    MGI:MGI:2443219
    See related
    Ensembl:ENSMUSG00000036339 AllianceGenome:MGI:2443219
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5930435P15; 6720456H20Rik
    Summary
    Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in protein maturation. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in T-cell non-Hodgkin lymphoma; non-Hodgkin lymphoma; and stomach cancer. Orthologous to human TMEM260 (transmembrane protein 260). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 8.9), ovary adult (RPKM 7.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem260 in Genome Data Viewer
    Location:
    14 C1; 14 25.06 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (48683580..48797640)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (48446123..48560183)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene actin related protein 2/3 complex, subunit 1A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:49041889-49042119 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8556 Neighboring gene STARR-seq mESC enhancer starr_36605 Neighboring gene STARR-seq mESC enhancer starr_36606 Neighboring gene STARR-seq mESC enhancer starr_36607 Neighboring gene STARR-seq mESC enhancer starr_36608 Neighboring gene RIKEN cDNA 4930572G02 gene Neighboring gene STARR-seq mESC enhancer starr_36609 Neighboring gene STARR-seq mESC enhancer starr_36610 Neighboring gene predicted gene, 35766

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein O-linked mannosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein O-mannosyl-transferase TMEM260
    Names
    UPF0679 protein C14orf101 homolog
    NP_001297513.1
    NP_766188.3
    XP_011243319.1
    XP_011243320.1
    XP_030103613.1
    XP_036014452.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310584.1 → NP_001297513.1  protein O-mannosyl-transferase TMEM260 isoform 2

      See identical proteins and their annotated locations for NP_001297513.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK031240, BC059217, BY085085
      Consensus CDS
      CCDS79318.1
      UniProtKB/Swiss-Prot
      Q8BMD6
      Related
      ENSMUSP00000118376.2, ENSMUST00000124720.8
      Conserved Domains (1) summary
      cl21590
      Location:1 → 51
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    2. NM_172600.4 → NP_766188.3  protein O-mannosyl-transferase TMEM260 isoform 1

      See identical proteins and their annotated locations for NP_766188.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK032809, AK141246, BC059217
      Consensus CDS
      CCDS26993.2
      UniProtKB/Swiss-Prot
      Q6GT69, Q80SZ4, Q8BMD6, Q8BMG3, Q8BW28, Q8BYU4
      UniProtKB/TrEMBL
      A0A2I3BQ91
      Related
      ENSMUSP00000107364.3, ENSMUST00000111735.10
      Conserved Domains (1) summary
      pfam11028
      Location:48 → 203
      DUF2723; Protein of unknown function (DUF2723)

    RNA

    1. NR_132324.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK031240, AK040456, AK141246, BC059217

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      48683580..48797640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245017.4 → XP_011243319.1  protein O-mannosyl-transferase TMEM260 isoform X3

      Conserved Domains (1) summary
      pfam11028
      Location:48 → 203
      DUF2723; Protein of unknown function (DUF2723)

    2. XM_011245018.4 → XP_011243320.1  protein O-mannosyl-transferase TMEM260 isoform X4

      Conserved Domains (1) summary
      pfam11028
      Location:48 → 203
      DUF2723; Protein of unknown function (DUF2723)

    3. XM_030247753.2 → XP_030103613.1  protein O-mannosyl-transferase TMEM260 isoform X2

      Conserved Domains (1) summary
      cl21590
      Location:1 → 51
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    4. XM_036158559.1 → XP_036014452.1  protein O-mannosyl-transferase TMEM260 isoform X1

      UniProtKB/TrEMBL
      A0A2I3BQ91
      Conserved Domains (1) summary
      cl21590
      Location:12 → 99
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    RNA

    1. XR_003950840.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMD6.2 GenPept UniProtKB/Swiss-Prot:Q8BMD6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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