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    Itgb1 integrin beta 1 (fibronectin receptor beta) [ Mus musculus (house mouse) ]

    Gene ID: 16412, updated on 9-Dec-2024

    Summary

    Official Symbol
    Itgb1provided by MGI
    Official Full Name
    integrin beta 1 (fibronectin receptor beta)provided by MGI
    Primary source
    MGI:MGI:96610
    See related
    Ensembl:ENSMUSG00000025809 AllianceGenome:MGI:96610
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD29; Fnrb; gpIIa; Gm9863; 4633401G24Rik
    Summary
    Enables integrin binding activity involved in cell-matrix adhesion and signaling receptor activity. Contributes to laminin binding activity. Involved in several processes, including basement membrane organization; cellular response to low-density lipoprotein particle stimulus; and regulation of synapse pruning. Acts upstream of or within with a negative effect on reactive gliosis and regulation of spontaneous synaptic transmission. Acts upstream of or within several processes, including circulatory system development; neuron projection morphogenesis; and regulation of transmembrane transport. Located in several cellular components, including intercalated disc; myelin sheath abaxonal region; and sarcolemma. Part of integrin alpha7-beta1 complex and integrin alpha9-beta1 complex. Is active in Schaffer collateral - CA1 synapse; cerebellar climbing fiber to Purkinje cell synapse; and synaptic membrane. Colocalizes with cytoplasmic vesicle; perinuclear region of cytoplasm; and plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and heart. Used to study Hirschsprung's disease. Orthologous to human ITGB1 (integrin subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 156.5), placenta adult (RPKM 75.5) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Itgb1 in Genome Data Viewer
    Location:
    8 E2; 8 76.09 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (129412135..129460060)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (128685654..128733579)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 26002 Neighboring gene STARR-seq mESC enhancer starr_23105 Neighboring gene coiled-coil domain containing 7A Neighboring gene predicted gene, 26100 Neighboring gene STARR-seq mESC enhancer starr_23108 Neighboring gene STARR-positive B cell enhancer mm9_chr8:131465278-131465579 Neighboring gene predicted gene, 22545

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (8) 
    • Targeted (27)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 39
    Function Evidence Code Pubs
    contributes_to C-X3-C chemokine binding  
    contributes_to C-X3-C chemokine binding  
    contributes_to C-X3-C chemokine binding  
    enables actin binding  
    enables actin binding  
    enables alpha-actinin binding  
    enables calcium ion binding  
    enables calcium ion binding  
    enables cell adhesion molecule binding  
    enables collagen binding  
    enables collagen binding involved in cell-matrix adhesion  
    enables collagen binding involved in cell-matrix adhesion  
    enables collagen binding involved in cell-matrix adhesion  
    enables fibronectin binding  
    enables fibronectin binding  
    enables fibronectin binding  
    enables integrin binding  
    enables integrin binding PubMed 
    enables integrin binding  
    enables integrin binding involved in cell-matrix adhesion PubMed 
    enables kinase binding  
    contributes_to laminin binding  
    contributes_to laminin binding PubMed 
    enables laminin binding  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables protease binding  
    enables protease binding  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein tyrosine kinase binding  
    enables protein tyrosine kinase binding  
    enables protein-containing complex binding  
    enables signaling receptor activity PubMed 
    enables signaling receptor binding  
    Items 1 - 25 of 39
    Items 1 - 25 of 111
    Process Evidence Code Pubs
    involved_in CD40 signaling pathway  
    involved_in CD40 signaling pathway  
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle PubMed 
    acts_upstream_of_or_within axon extension PubMed 
    acts_upstream_of_or_within axon extension PubMed 
    involved_in basement membrane organization PubMed 
    involved_in bicellular tight junction assembly  
    acts_upstream_of_or_within calcium-independent cell-matrix adhesion  
    acts_upstream_of_or_within cardiac cell fate specification PubMed 
    acts_upstream_of_or_within cardiac muscle cell differentiation PubMed 
    acts_upstream_of_or_within cardiac muscle cell myoblast differentiation PubMed 
    involved_in cell adhesion  
    involved_in cell adhesion mediated by integrin  
    involved_in cell adhesion mediated by integrin  
    involved_in cell adhesion mediated by integrin  
    involved_in cell migration  
    acts_upstream_of_or_within cell migration involved in sprouting angiogenesis PubMed 
    acts_upstream_of cell population proliferation PubMed 
    involved_in cell projection organization  
    involved_in cell-cell adhesion  
    involved_in cell-cell adhesion mediated by integrin  
    involved_in cell-matrix adhesion  
    acts_upstream_of_or_within cell-matrix adhesion PubMed 
    acts_upstream_of_or_within cell-matrix adhesion PubMed 
    involved_in cell-matrix adhesion  
    involved_in cell-matrix adhesion PubMed 
    involved_in cell-substrate adhesion  
    involved_in cellular response to low-density lipoprotein particle stimulus PubMed 
    acts_upstream_of_or_within dendrite morphogenesis PubMed 
    acts_upstream_of_or_within dendrite morphogenesis PubMed 
    involved_in establishment of mitotic spindle orientation  
    involved_in establishment of mitotic spindle orientation  
    acts_upstream_of_or_within formation of radial glial scaffolds PubMed 
    acts_upstream_of_or_within germ cell migration PubMed 
    involved_in heterotypic cell-cell adhesion  
    involved_in heterotypic cell-cell adhesion  
    acts_upstream_of_or_within in utero embryonic development PubMed 
    involved_in integrin-mediated signaling pathway  
    involved_in integrin-mediated signaling pathway  
    involved_in integrin-mediated signaling pathway PubMed 
    involved_in lamellipodium assembly  
    involved_in leukocyte cell-cell adhesion  
    involved_in leukocyte cell-cell adhesion PubMed 
    involved_in leukocyte tethering or rolling  
    involved_in leukocyte tethering or rolling  
    involved_in maintenance of postsynaptic specialization structure  
    involved_in mesodermal cell differentiation  
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in muscle organ development  
    involved_in myoblast differentiation  
    acts_upstream_of_or_within myoblast fate specification PubMed 
    involved_in myoblast fusion  
    acts_upstream_of_or_within negative regulation of Rho protein signal transduction PubMed 
    involved_in negative regulation of anoikis  
    involved_in negative regulation of anoikis  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell projection organization  
    acts_upstream_of_or_within negative regulation of neuron differentiation PubMed 
    involved_in negative regulation of neuron differentiation  
    involved_in negative regulation of vasoconstriction  
    involved_in negative regulation of vasoconstriction  
    acts_upstream_of neuroblast proliferation PubMed 
    acts_upstream_of neuron differentiation PubMed 
    acts_upstream_of_or_within neuron projection development PubMed 
    involved_in phagocytosis  
    involved_in positive regulation of GTPase activity  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of angiogenesis  
    acts_upstream_of_or_within positive regulation of apoptotic process  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell-substrate adhesion  
    involved_in positive regulation of endocytosis  
    involved_in positive regulation of fibroblast growth factor receptor signaling pathway  
    involved_in positive regulation of fibroblast growth factor receptor signaling pathway  
    involved_in positive regulation of fibroblast migration  
    involved_in positive regulation of fibroblast migration  
    acts_upstream_of_or_within positive regulation of glutamate uptake involved in transmission of nerve impulse PubMed 
    acts_upstream_of_or_within positive regulation of neuroblast proliferation PubMed 
    involved_in positive regulation of neuron differentiation  
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of protein localization to plasma membrane  
    involved_in positive regulation of protein localization to plasma membrane  
    involved_in positive regulation of vascular endothelial growth factor signaling pathway  
    involved_in positive regulation of vascular endothelial growth factor signaling pathway  
    involved_in positive regulation of wound healing  
    involved_in positive regulation of wound healing  
    involved_in protein transport within lipid bilayer  
    acts_upstream_of_or_within_negative_effect reactive gliosis PubMed 
    involved_in receptor internalization PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway  
    acts_upstream_of_or_within regulation of cell cycle PubMed 
    involved_in regulation of collagen catabolic process  
    involved_in regulation of collagen catabolic process  
    acts_upstream_of_or_within regulation of inward rectifier potassium channel activity PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping  
    acts_upstream_of_or_within_negative_effect regulation of spontaneous synaptic transmission PubMed 
    involved_in regulation of synapse pruning PubMed 
    involved_in regulation of synapse pruning PubMed 
    involved_in response to muscle activity PubMed 
    acts_upstream_of_or_within sarcomere organization PubMed 
    NOT involved_in stress fiber assembly PubMed 
    involved_in tissue homeostasis  
    NOT involved_in transforming growth factor beta receptor signaling pathway PubMed 
    acts_upstream_of_or_within visual learning PubMed 
    acts_upstream_of_or_within visual learning PubMed 
    Items 1 - 25 of 111
    Items 1 - 20 of 78
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    located_in acrosomal vesicle  
    located_in adherens junction  
    located_in basement membrane  
    is_active_in cell surface  
    located_in cell surface PubMed 
    located_in cell surface PubMed 
    located_in cell-cell junction  
    is_active_in cerebellar climbing fiber to Purkinje cell synapse PubMed 
    is_active_in cerebellar climbing fiber to Purkinje cell synapse PubMed 
    located_in cytoplasm  
    colocalizes_with cytoplasmic vesicle PubMed 
    located_in dendritic spine PubMed 
    located_in dendritic spine  
    located_in external side of plasma membrane PubMed 
    located_in filopodium  
    located_in filopodium  
    is_active_in focal adhesion  
    colocalizes_with focal adhesion  
    located_in focal adhesion PubMed 
    located_in focal adhesion  
    located_in glial cell projection  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    is_active_in glycinergic synapse  
    located_in hemidesmosome  
    part_of integrin alpha1-beta1 complex  
    part_of integrin alpha1-beta1 complex  
    part_of integrin alpha10-beta1 complex  
    part_of integrin alpha10-beta1 complex  
    part_of integrin alpha11-beta1 complex  
    part_of integrin alpha11-beta1 complex  
    part_of integrin alpha2-beta1 complex  
    part_of integrin alpha2-beta1 complex  
    part_of integrin alpha3-beta1 complex  
    part_of integrin alpha3-beta1 complex  
    part_of integrin alpha4-beta1 complex  
    part_of integrin alpha5-beta1 complex  
    part_of integrin alpha5-beta1 complex  
    part_of integrin alpha6-beta1 complex  
    part_of integrin alpha6-beta1 complex  
    part_of integrin alpha7-beta1 complex PubMed 
    part_of integrin alpha7-beta1 complex PubMed 
    part_of integrin alpha9-beta1 complex PubMed 
    part_of integrin alpha9-beta1 complex  
    part_of integrin alphav-beta1 complex  
    part_of integrin alphav-beta1 complex  
    part_of integrin complex  
    part_of integrin complex  
    located_in intercalated disc PubMed 
    located_in lamellipodium  
    located_in melanosome  
    located_in membrane PubMed 
    located_in membrane raft  
    located_in membrane raft  
    located_in myelin sheath abaxonal region PubMed 
    located_in neuromuscular junction PubMed 
    located_in neuromuscular junction  
    colocalizes_with perinuclear region of cytoplasm PubMed 
    located_in perinuclear region of cytoplasm  
    colocalizes_with plasma membrane PubMed 
    is_active_in plasma membrane PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic membrane  
    located_in postsynaptic membrane  
    part_of receptor complex PubMed 
    located_in recycling endosome  
    located_in ruffle membrane  
    colocalizes_with ruffle membrane  
    located_in sarcolemma PubMed 
    located_in sarcolemma  
    is_active_in synapse  
    located_in synapse PubMed 
    is_active_in synaptic membrane PubMed 
    located_in synaptic membrane PubMed 
    Items 1 - 20 of 78

    General protein information

    Preferred Names
    integrin beta-1
    Names
    VLA-4 subunit beta
    fibronectin receptor subunit beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010578.2NP_034708.1  integrin beta-1 precursor

      See identical proteins and their annotated locations for NP_034708.1

      Status: VALIDATED

      Source sequence(s)
      AC156608, BC050906
      Consensus CDS
      CCDS22791.1
      UniProtKB/Swiss-Prot
      F6R105, P09055, Q3TIW5, Q3TWH6, Q60993, Q61126, Q8BTU0, Q8BVU1
      Related
      ENSMUSP00000087457.6, ENSMUST00000090006.12
      Conserved Domains (5) summary
      smart00187
      Location:34464
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07974
      Location:602630
      EGF_2; EGF-like domain
      pfam07965
      Location:640727
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:757795
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      pfam18372
      Location:466495
      I-EGF_1; Integrin beta epidermal growth factor like domain 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      129412135..129460060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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