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    Dclk2 doublecortin-like kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 70762, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dclk2provided by MGI
    Official Full Name
    doublecortin-like kinase 2provided by MGI
    Primary source
    MGI:MGI:1918012
    See related
    Ensembl:ENSMUSG00000028078 AllianceGenome:MGI:1918012
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CL2; CLICK2; Dcamkl2; Click-II; 6330415M09Rik
    Summary
    This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. This gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
    Expression
    Biased expression in whole brain E14.5 (RPKM 41.0), CNS E14 (RPKM 37.3) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dclk2 in Genome Data Viewer
    Location:
    3 F1; 3 37.88 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (86693457..86828292, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (86786150..86920952, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene LPS-responsive beige-like anchor Neighboring gene thymosin, beta 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08131 Neighboring gene predicted gene, 52625 Neighboring gene STARR-seq mESC enhancer starr_08132 Neighboring gene STARR-positive B cell enhancer ABC_E6065 Neighboring gene STARR-seq mESC enhancer starr_08133 Neighboring gene predicted gene, 46810 Neighboring gene STARR-seq mESC enhancer starr_08138 Neighboring gene STARR-seq mESC enhancer starr_08141 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:86790904-86791087 Neighboring gene predicted gene, 23376 Neighboring gene CD1d2 antigen

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural studies of the doublecortin family of MAPs. Fourniol F, et al. Methods Cell Biol, 2013. PMID 23973064
    2. Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by chronic cerebral ischemia through phosphorylation of Ehf. Sun M, et al. J Cereb Blood Flow Metab, 2024 Sep. PMID 38513137,
    3. Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation. Shin E, et al. Nat Commun, 2013. PMID 23385585, Free PMC Article
    4. Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Nawabi H, et al. Neuron, 2015 Nov 18. PMID 26526391, Free PMC Article
    5. Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice. Tuy FP, et al. Dev Neurosci, 2008. PMID 18075264

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by chronic cerebral ischemia through phosphorylation of Ehf.
      Title: Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by chronic cerebral ischemia through phosphorylation of Ehf.
    2. Dclk2 promotes axonal regeneration, neuronal survival, and growth core reformation via microtubule stabilization, prevention of F-actin destabilization and synergy with mTOR.
      Title: Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms.
    3. Doublecortin-like kinases are critical regulators of dendritic development by means of their specific targeting to the distal dendrites, and their local control of dendritic growth and synapse maturation.
      Title: Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation.
    4. Dcx; Dclk2-null mice display frequent spontaneous seizures that originate in the hippocampus, with most animals dying in the first few months of life.
      Title: Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hippocampus development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pyramidal neuron development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase DCLK2
    Names
    caMK-like CREB regulatory kinase 2
    doublecortin and CaM kinase-like 2
    doublecortin-like and CAM kinase-like 2
    NP_001182425.1
    NP_001182426.1
    NP_001182427.1
    NP_001182428.1
    NP_001182429.1
    NP_001344389.1
    NP_081815.3
    XP_006502129.1
    XP_006502130.1
    XP_006502131.1
    XP_006502132.1
    XP_006502133.1
    XP_006502134.1
    XP_006502135.1
    XP_006502136.1
    XP_006502137.1
    XP_006502138.1
    XP_006502139.1
    XP_006502140.1
    XP_006502141.1
    XP_011238528.1
    XP_011238529.1
    XP_017175208.1
    XP_030108678.1
    XP_030108679.1
    XP_030108680.1
    XP_030108681.1
    XP_030108682.1
    XP_030108683.1
    XP_036019200.1
    XP_036019201.1
    XP_036019202.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195496.1 → NP_001182425.1  serine/threonine-protein kinase DCLK2 isoform 1

      See identical proteins and their annotated locations for NP_001182425.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is an exon-5-containing transcript (PMIDs:15611072 and 18075264), and encodes the longest isoform (1).
      Source sequence(s)
      AC102164, AC127237, AC132346
      UniProtKB/TrEMBL
      A0A0A6YX71
      Conserved Domains (3) summary
      smart00220
      Location:408 → 665
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:406 → 664
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001195497.1 → NP_001182426.1  serine/threonine-protein kinase DCLK2 isoform 3

      See identical proteins and their annotated locations for NP_001182426.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is an exon-5-lacking transcript (PMIDs:15611072 and 18075264). It lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK049179, BC056921, BQ771344, BY361646
      Consensus CDS
      CCDS79936.1
      UniProtKB/TrEMBL
      A0A0A6YX71
      Related
      ENSMUSP00000142267.2, ENSMUST00000195561.6
      Conserved Domains (3) summary
      smart00220
      Location:392 → 649
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:390 → 648
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001195498.1 → NP_001182427.1  serine/threonine-protein kinase DCLK2 isoform 4

      See identical proteins and their annotated locations for NP_001182427.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) is an exon-5-containing and exon-17-containing transcript (PMIDs:15611072 and 18075264), and represents the longest transcript. It has an additional 3 nts at an alternate splice site and an additional exon in the 3' region, which results in frame-shift, as compared to variant 1. The resulting isoform (4) has an extra aa in the middle region and has a shorter and different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC102164, AC127237, AC132346
      UniProtKB/TrEMBL
      A0A0A6YX71
      Conserved Domains (3) summary
      smart00220
      Location:409 → 666
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:407 → 665
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001195499.1 → NP_001182428.1  serine/threonine-protein kinase DCLK2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) is an exon-5-containing and exon-17-containing transcript (PMIDs:15611072 and 18075264). It has an additional exon in the 3' region, which results in frame-shift, as compared to variant 1. The resulting isoform (5) has a shorter and different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC102164, AC127237, AC132346
      UniProtKB/TrEMBL
      A0A0A6YX71
      Conserved Domains (3) summary
      smart00220
      Location:408 → 665
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:406 → 664
      PKc_like; Protein Kinases, catalytic domain

    5. NM_001195500.2 → NP_001182429.1  serine/threonine-protein kinase DCLK2 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) is an exon-5-lacking transcript (PMIDs:15611072 and 18075264). It lacks an internal exon and several 3' exons, but has an alternate 3' segment, as compared to variant 1. The resulting isoform (6) lacks an internal segment and is C-terminal truncated, as compared to isoform 1.
      Source sequence(s)
      AK049126, BQ771344
      Consensus CDS
      CCDS79935.1
      UniProtKB/TrEMBL
      A0A0A6YWI6, A0A0A6YX33
      Related
      ENSMUSP00000141816.2, ENSMUST00000194452.2
      Conserved Domains (3) summary
      smart00220
      Location:392 → 590
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:390 → 590
      PKc_like; Protein Kinases, catalytic domain

    6. NM_001357460.1 → NP_001344389.1  serine/threonine-protein kinase DCLK2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC102164, AC127237, AC132346
      UniProtKB/TrEMBL
      A0A0A6YX71
      Conserved Domains (2) summary
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:407 → 665
      PKc_like; Protein Kinases, catalytic domain

    7. NM_027539.5 → NP_081815.3  serine/threonine-protein kinase DCLK2 isoform 2

      See identical proteins and their annotated locations for NP_081815.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is an exon-5-lacking transcript (PMIDs:15611072 and 18075264). It lacks an in-frame coding exon and has an additional 3 nts at an alternate splice site, as compared to variant 1. The resulting isoform (2) is shorter; it lacks an internal segment but has a downstream extra aa, as compared to isoform 1.
      Source sequence(s)
      BC056921, BQ771344, BY361646
      Consensus CDS
      CCDS17448.1
      UniProtKB/Swiss-Prot
      Q1EDG7, Q1EDG8, Q4H483, Q4W8V1, Q6PGN3, Q8BUU0, Q8BX25
      UniProtKB/TrEMBL
      A0A0A6YX71
      Related
      ENSMUSP00000029719.9, ENSMUST00000029719.14
      Conserved Domains (3) summary
      smart00220
      Location:393 → 650
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:391 → 649
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      86693457..86828292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252823.2 → XP_030108683.1  serine/threonine-protein kinase DCLK2 isoform X23

      UniProtKB/TrEMBL
      A0A0A6YWI6
      Related
      ENSMUSP00000141567.2, ENSMUST00000192773.6
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:390 → 637
      PKc_like; Protein Kinases, catalytic domain

    2. XM_030252818.2 → XP_030108678.1  serine/threonine-protein kinase DCLK2 isoform X5

      UniProtKB/TrEMBL
      A0A0A6YX71
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:390 → 638
      PKc_like; Protein Kinases, catalytic domain

    3. XM_030252821.2 → XP_030108681.1  serine/threonine-protein kinase DCLK2 isoform X18

      UniProtKB/TrEMBL
      A0A0A6YX71
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:390 → 648
      PKc_like; Protein Kinases, catalytic domain

    4. XM_006502071.4 → XP_006502134.1  serine/threonine-protein kinase DCLK2 isoform X10

      UniProtKB/TrEMBL
      A0A0A6YX71
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:390 → 648
      PKc_like; Protein Kinases, catalytic domain

    5. XM_030252822.2 → XP_030108682.1  serine/threonine-protein kinase DCLK2 isoform X22

      UniProtKB/TrEMBL
      A0A0A6YWI6
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:391 → 638
      PKc_like; Protein Kinases, catalytic domain

    6. XM_006502067.4 → XP_006502130.1  serine/threonine-protein kinase DCLK2 isoform X4

      UniProtKB/TrEMBL
      A0A0A6YX71
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:391 → 639
      PKc_like; Protein Kinases, catalytic domain

    7. XM_030252820.2 → XP_030108680.1  serine/threonine-protein kinase DCLK2 isoform X17

      UniProtKB/TrEMBL
      A0A0A6YX71
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:391 → 649
      PKc_like; Protein Kinases, catalytic domain

    8. XM_030252819.2 → XP_030108679.1  serine/threonine-protein kinase DCLK2 isoform X9

      UniProtKB/TrEMBL
      A0A0A6YX71
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:391 → 649
      PKc_like; Protein Kinases, catalytic domain

    9. XM_036163308.1 → XP_036019201.1  serine/threonine-protein kinase DCLK2 isoform X3

      UniProtKB/TrEMBL
      A0A0A6YX71
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:406 → 654
      PKc_like; Protein Kinases, catalytic domain

    10. XM_036163309.1 → XP_036019202.1  serine/threonine-protein kinase DCLK2 isoform X13

      UniProtKB/TrEMBL
      A0A0A6YX71
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:406 → 664
      PKc_like; Protein Kinases, catalytic domain

    11. XM_011240226.3 → XP_011238528.1  serine/threonine-protein kinase DCLK2 isoform X11

      UniProtKB/TrEMBL
      A0A0A6YWI6
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407 → 607
      PKc_like; Protein Kinases, catalytic domain

    12. XM_017319719.3 → XP_017175208.1  serine/threonine-protein kinase DCLK2 isoform X24

      UniProtKB/TrEMBL
      A0A0A6YWI6
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407 → 607
      PKc_like; Protein Kinases, catalytic domain

    13. XM_011240227.3 → XP_011238529.1  serine/threonine-protein kinase DCLK2 isoform X25

      UniProtKB/TrEMBL
      A0A0A6YWI6
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407 → 607
      PKc_like; Protein Kinases, catalytic domain

    14. XM_006502076.4 → XP_006502139.1  serine/threonine-protein kinase DCLK2 isoform X19

      UniProtKB/TrEMBL
      A0A0A6YWI6
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407 → 654
      PKc_like; Protein Kinases, catalytic domain

    15. XM_006502070.4 → XP_006502133.1  serine/threonine-protein kinase DCLK2 isoform X8

      UniProtKB/TrEMBL
      A0A0A6YWI6
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407 → 659
      PKc_like; Protein Kinases, catalytic domain

    16. XM_006502078.4 → XP_006502141.1  serine/threonine-protein kinase DCLK2 isoform X21

      UniProtKB/TrEMBL
      A0A0A6YWI6
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407 → 654
      PKc_like; Protein Kinases, catalytic domain

    17. XM_006502066.4 → XP_006502129.1  serine/threonine-protein kinase DCLK2 isoform X2

      UniProtKB/TrEMBL
      A0A0A6YX71
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407 → 655
      PKc_like; Protein Kinases, catalytic domain

    18. XM_006502074.4 → XP_006502137.1  serine/threonine-protein kinase DCLK2 isoform X15

      UniProtKB/TrEMBL
      A0A0A6YX71
      Related
      ENSMUSP00000141707.2, ENSMUST00000191752.6
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407 → 655
      PKc_like; Protein Kinases, catalytic domain

    19. XM_006502072.4 → XP_006502135.1  serine/threonine-protein kinase DCLK2 isoform X12

      UniProtKB/TrEMBL
      A0A0A6YX71
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407 → 665
      PKc_like; Protein Kinases, catalytic domain

    20. XM_006502068.4 → XP_006502131.1  serine/threonine-protein kinase DCLK2 isoform X6

      UniProtKB/TrEMBL
      A0A0A6YX71
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407 → 665
      PKc_like; Protein Kinases, catalytic domain

    21. XM_006502075.4 → XP_006502138.1  serine/threonine-protein kinase DCLK2 isoform X16

      UniProtKB/TrEMBL
      A0A0A6YX71
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407 → 665
      PKc_like; Protein Kinases, catalytic domain

    22. XM_006502069.4 → XP_006502132.1  serine/threonine-protein kinase DCLK2 isoform X7

      UniProtKB/TrEMBL
      A0A0A6YX71
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407 → 665
      PKc_like; Protein Kinases, catalytic domain

    23. XM_006502077.4 → XP_006502140.1  serine/threonine-protein kinase DCLK2 isoform X20

      UniProtKB/TrEMBL
      A0A0A6YWI6
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407 → 655
      PKc_like; Protein Kinases, catalytic domain

    24. XM_006502073.4 → XP_006502136.1  serine/threonine-protein kinase DCLK2 isoform X14

      UniProtKB/TrEMBL
      A0A0A6YX71
      Related
      ENSMUSP00000141866.2, ENSMUST00000193632.6
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407 → 665
      PKc_like; Protein Kinases, catalytic domain

    25. XM_036163307.1 → XP_036019200.1  serine/threonine-protein kinase DCLK2 isoform X1

      UniProtKB/TrEMBL
      A0A0A6YWI6
      Conserved Domains (3) summary
      cd17069
      Location:192 → 275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:390 → 648
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_003954386.2 RNA Sequence

    2. XR_003954385.2 RNA Sequence

    3. XR_003954383.2 RNA Sequence

    4. XR_004941394.1 RNA Sequence

    5. XR_004941393.1 RNA Sequence

    6. XR_003954382.2 RNA Sequence

    7. XR_867231.4 RNA Sequence

    8. XR_003954387.2 RNA Sequence

    9. XR_867229.3 RNA Sequence

    10. XR_003954384.2 RNA Sequence

    11. XR_004941392.1 RNA Sequence

    12. XR_003954381.2 RNA Sequence

    13. XR_001783745.3 RNA Sequence

    14. XR_004941391.1 RNA Sequence

    15. XR_004941390.1 RNA Sequence

    16. XR_867230.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PGN3.1 GenPept UniProtKB/Swiss-Prot:Q6PGN3

    Gene LinkOut

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