Cxxc5 CXXC finger 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cxxc5provided by MGI
Official Full Name: CXXC finger 5provided by MGI
Primary source: MGI:MGI:1914643
See related: Ensembl:ENSMUSG00000046668 AllianceGenome:MGI:1914643
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930415K17Rik
Summary: Predicted to enable DNA-binding transcription factor binding activity; methyl-CpG binding activity; and zinc ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and regulation of generation of precursor metabolites and energy. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human CXXC5 (CXXC finger protein 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 24.2), testis adult (RPKM 22.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B2; 18 19.26 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (35962432..35994746)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (35829379..35861693)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CXXC5 mitigates P. gingivalis-inhibited cementogenesis by influencing mitochondrial biogenesis.
Title: CXXC5 mitigates P. gingivalis-inhibited cementogenesis by influencing mitochondrial biogenesis.
Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair.
Title: Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair.
Inhibition of CXXC5 function rescues Alzheimer's disease phenotypes by restoring Wnt/beta-catenin signaling pathway.
Title: Inhibition of CXXC5 function rescues Alzheimer's disease phenotypes by restoring Wnt/β-catenin signaling pathway.
Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment.
Title: Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment.
Inhibition of CXXC5 function reverses obesity-related metabolic diseases.
Title: Inhibition of CXXC5 function reverses obesity-related metabolic diseases.
CXXC5 orchestrates Stat3/Erk/Akt signaling networks to modulate P. gingivalis-elicited autophagy in cementoblasts.
Title: CXXC5 orchestrates Stat3/Erk/Akt signaling networks to modulate P. gingivalis-elicited autophagy in cementoblasts.
CXXC5 Attenuates Pulmonary Fibrosis in a Bleomycin-Induced Mouse Model and MLFs by Suppression of the CD40/CD40L Pathway.
Title: CXXC5 Attenuates Pulmonary Fibrosis in a Bleomycin-Induced Mouse Model and MLFs by Suppression of the CD40/CD40L Pathway.
Rinf Regulates Pluripotency Network Genes and Tet Enzymes in Embryonic Stem Cells.
Title: Rinf Regulates Pluripotency Network Genes and Tet Enzymes in Embryonic Stem Cells.
These results reveal an important role for CXXC5 as a suppressor of longitudinal bone growth involving growth plate activity.
Title: CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth.
Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.
Title: Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables methyl-CpG binding	IBA Inferred from Biological aspect of Ancestor more info
enables methyl-CpG binding	ISO Inferred from Sequence Orthology more info
enables methyl-CpG binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of generation of precursor metabolites and energy	IEA Inferred from Electronic Annotation more info
involved_in regulation of generation of precursor metabolites and energy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CXXC-type zinc finger protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357458.1 → NP_001344387.1 CXXC-type zinc finger protein 5

Status: VALIDATED

Source sequence(s)

AC141471, AI843749

Consensus CDS

CCDS29150.1

UniProtKB/Swiss-Prot

Q3V0R4, Q8CES6, Q8CF49, Q91WA4

Conserved Domains (1) summary

pfam02008
Location:250 → 291

zf-CXXC; CXXC zinc finger domain
NM_001357459.1 → NP_001344388.1 CXXC-type zinc finger protein 5

Status: VALIDATED

Source sequence(s)

AC141471, AI843749, AK132950, BC089314

Consensus CDS

CCDS29150.1

UniProtKB/Swiss-Prot

Q3V0R4, Q8CES6, Q8CF49, Q91WA4

Conserved Domains (1) summary

pfam02008
Location:250 → 291

zf-CXXC; CXXC zinc finger domain
NM_133687.3 → NP_598448.1 CXXC-type zinc finger protein 5

See identical proteins and their annotated locations for NP_598448.1

Status: VALIDATED

Source sequence(s)

AI843749, BC089314, BY705532

Consensus CDS

CCDS29150.1

UniProtKB/Swiss-Prot

Q3V0R4, Q8CES6, Q8CF49, Q91WA4

Related

ENSMUSP00000054307.7, ENSMUST00000060722.8

Conserved Domains (1) summary

pfam02008
Location:250 → 291

zf-CXXC; CXXC zinc finger domain