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    CG4461 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39074, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4461provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035982
    Locus tag
    Dmel_CG4461
    See related
    AllianceGenome:FB:FBgn0035982
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    148460_at; 4461; BEST:GH12586; DmCG4461; Dmel23.8; Dmel\CG4461; gh12586; Hsp20
    Summary
    Predicted to enable unfolded protein binding activity. Involved in response to heat. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4461 in Genome Data Viewer
    Location:
    67B2-67B2; 3-29 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9375430..9376293)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9368530..9369393)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Heat shock gene 67Bc Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 22 Neighboring gene Heat shock protein 26 Neighboring gene antisense RNA:CR43481 Neighboring gene Heat shock gene 67Ba

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the shsp genes in Drosophila buzzatii and association between the frequency of Valine mutations in hsp23 and climatic variables along a longitudinal gradient in Australia. Frydenberg J, et al. Cell Stress Chaperones, 2010 May. PMID 19806471, Free PMC Article
    2. Effects of different small HSPB members on contractile dysfunction and structural changes in a Drosophila melanogaster model for Atrial Fibrillation. Zhang D, et al. J Mol Cell Cardiol, 2011 Sep. PMID 21745477
    3. Coincidence of P-insertion sites and breakpoints of deletions induced by activating P elements in Drosophila. Sudi J, et al. Genetics, 2008 May. PMID 18493052, Free PMC Article
    4. Drosophila small heat shock proteins: cell and organelle-specific chaperones? Michaud S, et al. Prog Mol Subcell Biol, 2002. PMID 11908067
    5. Specific protein homeostatic functions of small heat-shock proteins increase lifespan. Vos MJ, et al. Aging Cell, 2016 Apr. PMID 26705243, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4461-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9375430..9376293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140047.2 → NP_648304.1  uncharacterized protein Dmel_CG4461 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648304.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSX2
      Related
      FBpp0076180
      Conserved Domains (1) summary
      cd06526
      Location:94 → 169
      metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSX2 Q9VSX2

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