Unc5a unc-5 netrin receptor A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Unc5aprovided by MGI
Official Full Name: unc-5 netrin receptor Aprovided by MGI
Primary source: MGI:MGI:894682
See related: Ensembl:ENSMUSG00000025876 AllianceGenome:MGI:894682
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Unc5h1; mKIAA1976
Summary: Predicted to enable netrin receptor activity. Acts upstream of or within anterior/posterior axon guidance. Predicted to be located in neuron projection membrane and neuronal cell body membrane. Is expressed in several structures, including brain; sensory organ; skeleton; ventral grey horn; and vibrissa follicle. Orthologous to human UNC5A (unc-5 netrin receptor A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in mammary gland adult (RPKM 18.5), adrenal adult (RPKM 16.6) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 29.8 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (55090545..55153831)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (54945151..55006018)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPC3-Unc5 receptor complex structure and role in cell migration.
Title: GPC3-Unc5 receptor complex structure and role in cell migration.
Mannosylation by DPY19L1 but not DPY19L3 is required for transport of UNC5A from the endoplasmic reticulum to the cell surface. In vertebrates, a new C-mannosyltransferase has apparently evolved to increase glycosylation of TSRs, potentially to increase the stability of the structurally essential tryptophan ladder or to provide additional adhesion functions.
Title: Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3.
UNC5A is a novel transcriptional target of p53 and plays a role in p53-dependent apoptosis
Title: Identification of UNC5A as a novel transcriptional target of tumor suppressor p53 and a regulator of apoptosis.
Findings suggest that DCC:UNC5H ratios in DA neurons at critical periods may have important consequences for the organization and function of mesocorticolimbic DA systems.
Title: Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents.
Unc5h1 was cloned; its expression is restricted to the central nervous system in developing mouse
Title: Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation.
a mechanism for UNC5H1-mediated apoptosis that requires an interaction with the MAGE protein NRAGE
Title: UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE.
Results suggest that UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1.
Title: UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Unc5a (e-PCR), detects polymorphism
- UniSTS:532695

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables netrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables netrin receptor activity	IEA Inferred from Electronic Annotation more info
enables netrin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterior/posterior axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within anterior/posterior axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in netrin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in netrin-activated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in neuron projection membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: netrin receptor UNC5A

Names: protein unc-5 homolog 1; protein unc-5 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311128.2 → NP_001298057.1 netrin receptor UNC5A isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC154610

Consensus CDS

CCDS79188.1

UniProtKB/Swiss-Prot

Q8K1S4

Related

ENSMUSP00000105621.3, ENSMUST00000109994.9

Conserved Domains (5) summary

smart00218
Location:439 → 542

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

smart00209
Location:245 → 293

TSP1; Thrombospondin type 1 repeats

pfam07679
Location:151 → 239

I-set; Immunoglobulin I-set domain

cd08800
Location:755 → 838

Death_UNC5A; Death domain found in Uncoordinated-5A

cl11960
Location:153 → 239

Ig; Immunoglobulin domain
NM_153131.5 → NP_694771.1 netrin receptor UNC5A isoform 1 precursor

See identical proteins and their annotated locations for NP_694771.1

Status: VALIDATED

Source sequence(s)

AC154610

Consensus CDS

CCDS26537.1

UniProtKB/Swiss-Prot

Q6PEF7, Q80T71, Q8K1S4

Related

ENSMUSP00000026994.8, ENSMUST00000026994.14

Conserved Domains (5) summary

smart00218
Location:495 → 598

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

smart00209
Location:245 → 296

TSP1; Thrombospondin type 1 repeats

pfam07679
Location:151 → 239

I-set; Immunoglobulin I-set domain

cd08800
Location:811 → 894

Death_UNC5A; Death domain found in Uncoordinated-5A

cl11960
Location:153 → 239

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

55090545..55153831

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006517037.3 → XP_006517100.2 netrin receptor UNC5A isoform X1

Conserved Domains (5) summary

smart00218
Location:670 → 773

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

smart00209
Location:420 → 471

TSP1; Thrombospondin type 1 repeats

cd08800
Location:986 → 1069

Death_UNC5A; Death domain found in Uncoordinated-5A

pfam17217
Location:820 → 959

UPA; UPA domain

cl11960
Location:328 → 414

Ig; Immunoglobulin domain
XM_006517038.3 → XP_006517101.2 netrin receptor UNC5A isoform X2

Conserved Domains (5) summary

smart00218
Location:614 → 717

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

smart00209
Location:420 → 468

TSP1; Thrombospondin type 1 repeats

cd08800
Location:930 → 1013

Death_UNC5A; Death domain found in Uncoordinated-5A

pfam17217
Location:764 → 903

UPA; UPA domain

cl11960
Location:328 → 414

Ig; Immunoglobulin domain