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    Lap1 Lap1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36670, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lap1provided by FlyBase
    Official Full Name
    Lap1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033984
    Locus tag
    Dmel_CG10255
    See related
    AllianceGenome:FB:FBgn0033984
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10255; CT28815; dlap1; dLap1; dLAP1; Dmel\CG10255; LRRC7
    Summary
    Predicted to be involved in establishment or maintenance of cell polarity and protein transport. Is expressed in adult head. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to several human genes including LRRC7 (leucine rich repeat containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lap1 in Genome Data Viewer
    Location:
    51D4-51D4; 2-73 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14935660..14940722)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10823165..10828227)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 317a1 Neighboring gene kank Neighboring gene Alkylglycerone phosphate synthase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene atypical protein kinase C Neighboring gene caskin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Collective nomenclature for LAP proteins. Bilder D, et al. Nat Cell Biol, 2000 Jul. PMID 10878817
    2. The LAP family: a phylogenetic point of view. Santoni MJ, et al. Trends Genet, 2002 Oct. PMID 12350333
    3. Cost-effective strategies for completing the interactome. Schwartz AS, et al. Nat Methods, 2009 Jan. PMID 19079254, Free PMC Article
    4. The Scribble family in cancer: twentieth anniversary. Santoni MJ, et al. Oncogene, 2020 Nov. PMID 32999444, Free PMC Article
    5. Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble. Zeitler J, et al. J Cell Biol, 2004 Dec 20. PMID 15611336, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in establishment or maintenance of cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Lap1
    Names
    CG10255-PA
    CG10255-PB
    Lap1-PA
    Lap1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14935660..14940722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202009.2 → NP_001188938.1  Lap1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188938.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V780
      UniProtKB/TrEMBL
      A0A0B4JCT8
      Conserved Domains (4) summary
      cd00116
      Location:21 → 200
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd00992
      Location:770 → 846
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00033
      Location:42 → 64
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:40 → 98
      LRR_8; Leucine rich repeat

    2. NM_137163.5 → NP_611007.1  Lap1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611007.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V780
      UniProtKB/TrEMBL
      A0A0B4JCT8
      Related
      FBpp0086538
      Conserved Domains (4) summary
      cd00116
      Location:21 → 200
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd00992
      Location:770 → 846
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00033
      Location:42 → 64
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:40 → 98
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JCT8 A0A0B4JCT8
    Q9V780.1 Q9V780

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