dila dilatory [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dilaprovided by FlyBase
Official Full Name: dilatoryprovided by FlyBase
Primary source: FLYBASE:FBgn0033447
Locus tag: Dmel_CG1625
See related: AllianceGenome:FB:FBgn0033447
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1625; CG1626; Dila; DILA; Dmel\CG1625
Summary: Involved in several processes, including cilium organization; peripheral nervous system neuron development; and protein localization to ciliary transition zone. Located in ciliary cap; ciliary transition zone; and microtubule organizing center. Is expressed in abdominal lateral pentascolopidial chordotonal organ lch5; elongation stage spermatid; peripheral sensory precursor cell; and sensory neurons. Orthologous to human CEP131 (centrosomal protein 131). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (9823082..9827206, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5710587..5714711, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Data implicate DILA in regulating intraflagellar transport at the base of sensory cilia.
Title: Dilatory is a Drosophila protein related to AZI1 (CEP131) that is located at the ciliary base and required for cilium formation.
Atonal directly regulates a novel gene, CG1625 (dilatory), that is directly associated with ciliogenesis during neuronal differentiation
Title: The gene regulatory cascade linking proneural specification with differentiation in Drosophila sensory neurons.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ciliary basal body-plasma membrane docking	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ciliary transition zone assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intraciliary transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intraciliary transport involved in cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in non-motile cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peripheral nervous system neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to ciliary transition zone	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of centrosome duplication	IBA Inferred from Biological aspect of Ancestor more info
involved_in sperm axoneme assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in centriolar satellite	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary cap	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary transition zone	IDA Inferred from Direct Assay more info	PubMed
located_in pericentriolar material	IDA Inferred from Direct Assay more info	PubMed

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