Dll3 delta like canonical Notch ligand 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dll3provided by MGI
Official Full Name: delta like canonical Notch ligand 3provided by MGI
Primary source: MGI:MGI:1096877
See related: Ensembl:ENSMUSG00000003436 AllianceGenome:MGI:1096877
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: pu; pudgy
Summary: Predicted to enable Notch binding activity. Involved in skeletal system development. Acts upstream of or within anterior/posterior pattern specification; negative regulation of neurogenesis; and paraxial mesoderm development. Located in plasma membrane. Is expressed in several structures, including blastocyst; central nervous system; future brain; paraxial mesenchyme; and sensory organ. Used to study spondylocostal dysostosis. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis 1. Orthologous to human DLL3 (delta like canonical Notch ligand 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E11.5 (RPKM 28.4), whole brain E14.5 (RPKM 11.7) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 16.67 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (27992980..28001210, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (28293555..28301785, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pudgy mouse rib deformities emanate from abnormal paravertebral longitudinal cartilage/bone accumulations.
Title: Pudgy mouse rib deformities emanate from abnormal paravertebral longitudinal cartilage/bone accumulations.
DLL3 expression and methylation are associated with lower-grade glioma immune microenvironment and prognosis.
Title: DLL3 expression and methylation are associated with lower-grade glioma immune microenvironment and prognosis.
Our data showed that activation of Respiratory syncytial virus (RSV) stimulated the differentiation of Th17 in airway microenvironment through activation Notch-1/DLL3, which may be associated with the occurrence and development of RSV-induced asthma.
Title: Respiratory syncytial virus promoted the differentiation of Th17 cells in airway microenvironment through activation of Notch-1/Delta3.
Structural deformities of the vertebral column and adjacent ribs in the pudgy mouse are caused by mutations in Dll3. Review.
Title: Disordered vertebral and rib morphology in pudgy mice. Structural relationships to human scoliosis.
Dll3 overexpression promoted PI3K/Akt signaling through inhibiting Notch signaling in lung cancer.
Title: The Notch ligand delta-like 3 promotes tumor growth and inhibits Notch signaling in lung cancer cells in mice.
O-fucosylation of DLL3 is required for its function during somitogenesis.
Title: O-fucosylation of DLL3 is required for its function during somitogenesis.
Intriguing changes are observed in the cranio-caudal borders of multifidus muscle in mutant Dll3 and Lfng models of idiopathic scoliosis.
Title: Mutations in the Notch pathway alter the patterning of multifidus.
Dll3 has a unique function during T-cell development that is distinct from the role played by the other DSL ligands of Notch.
Title: A cell autonomous role for the Notch ligand Delta-like 3 in αβ T-cell development.
Dll3 targets Notch1 for lysosomal degradation preventing Notch1 from undergoing post-translational processing.
Title: Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis.
Dll3 are expressed in the developing mouse eye and in retinal progenitor cell.
Title: Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Radiation induced (1)
Spontaneous (3) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dll3 (e-PCR), detects polymorphism
- UniSTS:142855

Dll3 (e-PCR), detects polymorphism
- UniSTS:259602

Dll3 (e-PCR), detects polymorphism
- UniSTS:465449

Y11895 (e-PCR)
- UniSTS:179543

D7Mit266 (e-PCR), detects polymorphism
- UniSTS:131162

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables Notch binding	ISO Inferred from Sequence Orthology more info
enables Notch binding	NAS Non-traceable Author Statement more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Notch signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in cell fate determination	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within compartment pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in in utero embryonic development	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neurogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within paraxial mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somitogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tissue development	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endosome membrane	TAS Traceable Author Statement more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: delta-like protein 3

Names: M-Delta-3; delta-like 3; delta3; drosophila Delta homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007866.2 → NP_031892.2 delta-like protein 3 precursor

See identical proteins and their annotated locations for NP_031892.2

Status: VALIDATED

Source sequence(s)

BB868475, BC052002

Consensus CDS

CCDS39856.1

UniProtKB/Swiss-Prot

O35675, O88516, Q80W06, Q9QWL9, Q9QWZ7

UniProtKB/TrEMBL

Q3UND5

Related

ENSMUSP00000103951.4, ENSMUST00000108315.4

Conserved Domains (3) summary

cd00054
Location:277 → 308

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07657
Location:25 → 85

MNNL; N terminus of Notch ligand

cl19567
Location:156 → 246

DSL; Delta serrate ligand