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    Usp44 ubiquitin specific peptidase 44 [ Mus musculus (house mouse) ]

    Gene ID: 327799, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Usp44provided by MGI
    Official Full Name
    ubiquitin specific peptidase 44provided by MGI
    Primary source
    MGI:MGI:3045318
    See related
    Ensembl:ENSMUSG00000020020 AllianceGenome:MGI:3045318
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E430004F17Rik
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Involved in chromosome segregation; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of mitotic cell cycle spindle assembly checkpoint. Located in nucleus. Orthologous to human USP44 (ubiquitin specific peptidase 44). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 24.5), CNS E11.5 (RPKM 1.5) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Usp44 in Genome Data Viewer
    Location:
    10 C2; 10 48.67 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93655831..93696792)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93819969..93859425)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_27591 Neighboring gene STARR-positive B cell enhancer mm9_chr10:93281373-93281673 Neighboring gene STARR-seq mESC enhancer starr_27592 Neighboring gene predicted gene, 26239 Neighboring gene STARR-seq mESC enhancer starr_27593 Neighboring gene methionine aminopeptidase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93352494-93352603 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93401444-93401825 Neighboring gene STARR-seq mESC enhancer starr_27594 Neighboring gene microRNA 331 Neighboring gene vezatin, adherens junctions transmembrane protein Neighboring gene mitochondrial inner membrane protease subunit 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. USP44 is dispensable for normal hematopoietic stem cell function, lymphocyte development, and B-cell-mediated immune response in a mouse model. Lin YH, et al. Exp Hematol, 2019 Apr. PMID 30639577
    2. USP44 inactivation accelerates the progression of thyroid cancer by inducing ubiquitylation and degradation of p21. Liu Y, et al. Int J Biol Sci, 2024. PMID 39430240, Free PMC Article
    3. RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation. Fuchs G, et al. Mol Cell, 2012 Jun 8. PMID 22681888, Free PMC Article
    4. Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia. Zhang Y, et al. PLoS One, 2011. PMID 21853124, Free PMC Article
    5. USP44 Stabilizes DDB2 to Facilitate Nucleotide Excision Repair and Prevent Tumors. Zhang Y, et al. Front Cell Dev Biol, 2021. PMID 33937266, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. USP44 is dispensable for the normal physiology of hematopoietic and immune systems, and its functions in these systems are likely redundant with other USP family proteins.
      Title: USP44 is dispensable for normal hematopoietic stem cell function, lymphocyte development, and B-cell-mediated immune response in a mouse model.
    2. USP44 inhibited chromosome segregation errors independent of its role in the mitotic checkpoint by regulating centrosome separation, positioning, and mitotic spindle geometry.
      Title: USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis.
    3. These data are consistent with an important role for USP44 in regulating Cdc20-APC/C activity and suggest that high levels of this enzyme may contribute to the pathogenesis of T-cell leukemias.
      Title: Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitotic metaphase/anaphase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulatory T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 44
    Names
    deubiquitinating enzyme 44
    inactive deubiquitinating enzyme 44
    inactive ubiquitin carboxyl-terminal hydrolase 44
    inactive ubiquitin thioesterase 44
    inactive ubiquitin-specific-processing protease 44
    ubiquitin specific peptidase 49 pseudogene
    ubiquitin thioesterase 44
    NP_001193780.1
    NP_001363910.1
    NP_001387910.1
    XP_011241782.1
    XP_011241783.1
    XP_011241784.1
    XP_011241785.1
    XP_011241786.1
    XP_011241787.1
    XP_011241788.1
    XP_011241789.1
    XP_011241790.1
    XP_011241791.1
    XP_011241792.1
    XP_030100994.1
    XP_030100996.1
    XP_036011718.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206851.3 → NP_001193780.1  ubiquitin carboxyl-terminal hydrolase 44

      See identical proteins and their annotated locations for NP_001193780.1

      Status: VALIDATED

      Source sequence(s)
      AC124686
      Consensus CDS
      CCDS88075.1
      UniProtKB/Swiss-Prot
      Q8C2S0
      Conserved Domains (2) summary
      pfam00443
      Location:272 → 674
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 88
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    2. NM_001376981.1 → NP_001363910.1  ubiquitin carboxyl-terminal hydrolase 44

      Status: VALIDATED

      Source sequence(s)
      AC124686
      UniProtKB/Swiss-Prot
      Q8C2S0
      Conserved Domains (2) summary
      pfam00443
      Location:272 → 674
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 88
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    3. NM_001400981.1 → NP_001387910.1  ubiquitin carboxyl-terminal hydrolase 44

      Status: VALIDATED

      Source sequence(s)
      AC124686
      UniProtKB/Swiss-Prot
      Q8C2S0
      Related
      ENSMUSP00000149020.2, ENSMUST00000216224.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      93655831..93696792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243480.4 → XP_011241782.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_011241782.1

      UniProtKB/Swiss-Prot
      Q8C2S0
      Conserved Domains (2) summary
      pfam00443
      Location:272 → 674
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 88
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    2. XM_011243484.3 → XP_011241786.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_011241786.1

      UniProtKB/Swiss-Prot
      Q8C2S0
      Conserved Domains (2) summary
      pfam00443
      Location:272 → 674
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 88
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    3. XM_011243483.3 → XP_011241785.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_011241785.1

      UniProtKB/Swiss-Prot
      Q8C2S0
      Conserved Domains (2) summary
      pfam00443
      Location:272 → 674
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 88
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    4. XM_011243485.3 → XP_011241787.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_011241787.1

      UniProtKB/Swiss-Prot
      Q8C2S0
      Conserved Domains (2) summary
      pfam00443
      Location:272 → 674
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 88
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    5. XM_011243481.4 → XP_011241783.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_011241783.1

      UniProtKB/Swiss-Prot
      Q8C2S0
      Conserved Domains (2) summary
      pfam00443
      Location:272 → 674
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 88
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    6. XM_011243487.4 → XP_011241789.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_011241789.1

      UniProtKB/Swiss-Prot
      Q8C2S0
      Conserved Domains (2) summary
      pfam00443
      Location:272 → 674
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 88
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    7. XM_011243489.4 → XP_011241791.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_011241791.1

      UniProtKB/Swiss-Prot
      Q8C2S0
      Conserved Domains (2) summary
      pfam00443
      Location:272 → 674
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 88
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    8. XM_030245136.2 → XP_030100996.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X2

      Conserved Domains (2) summary
      pfam00443
      Location:272 → 480
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 88
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    9. XM_011243490.4 → XP_011241792.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_011241792.1

      UniProtKB/Swiss-Prot
      Q8C2S0
      Conserved Domains (2) summary
      pfam00443
      Location:272 → 674
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 88
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    10. XM_011243482.3 → XP_011241784.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_011241784.1

      UniProtKB/Swiss-Prot
      Q8C2S0
      Conserved Domains (2) summary
      pfam00443
      Location:272 → 674
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 88
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    11. XM_030245134.2 → XP_030100994.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      UniProtKB/Swiss-Prot
      Q8C2S0
      Conserved Domains (2) summary
      pfam00443
      Location:272 → 674
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 88
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    12. XM_036155825.1 → XP_036011718.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X2

      Conserved Domains (2) summary
      pfam00443
      Location:272 → 480
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 88
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    13. XM_011243486.3 → XP_011241788.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_011241788.1

      UniProtKB/Swiss-Prot
      Q8C2S0
      Conserved Domains (2) summary
      pfam00443
      Location:272 → 674
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 88
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    14. XM_011243488.3 → XP_011241790.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_011241790.1

      UniProtKB/Swiss-Prot
      Q8C2S0
      Conserved Domains (2) summary
      pfam00443
      Location:272 → 674
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 88
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_183199.3: Suppressed sequence

      Description
      NM_183199.3: This RefSeq was removed because currently there is insufficient support for this transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C2S0.3 GenPept UniProtKB/Swiss-Prot:Q8C2S0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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