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    Impact impact, RWD domain protein [ Mus musculus (house mouse) ]

    Gene ID: 16210, updated on 9-Dec-2024

    Summary

    Official Symbol
    Impactprovided by MGI
    Official Full Name
    impact, RWD domain proteinprovided by MGI
    Primary source
    MGI:MGI:1098233
    See related
    Ensembl:ENSMUSG00000024423 AllianceGenome:MGI:1098233
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E430016J11Rik
    Summary
    Enables actin binding activity; protein sequestering activity; and ribosome binding activity. Involved in several processes, including GCN2-mediated signaling; cellular response to amino acid starvation; and regulation of gene expression. Acts upstream of or within negative regulation of protein phosphorylation and regulation of translational initiation. Located in cytoplasm. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human IMPACT (impact RWD domain protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 16.8), cerebellum adult (RPKM 14.5) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Impact in Genome Data Viewer
    Location:
    18 A1; 18 6.87 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (13087747..13126007)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (12954690..12992950)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 1A Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:12966807-12966996 Neighboring gene predicted gene, 36439 Neighboring gene STARR-seq mESC enhancer starr_43844 Neighboring gene STARR-seq mESC enhancer starr_43846 Neighboring gene STARR-seq mESC enhancer starr_43847 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9448 Neighboring gene histamine receptor H4 Neighboring gene ribosomal protein SA pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein sequestering activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    protein IMPACT
    Names
    imprinted and ancient gene protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357396.1 → NP_001344325.1  protein IMPACT isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC131672, BM899561
      Conserved Domains (2) summary
      smart00591
      Location:1 → 97
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      pfam01205
      Location:164 → 270
      UPF0029; Uncharacterized protein family UPF0029
    2. NM_008378.3 → NP_032404.1  protein IMPACT isoform 1

      See identical proteins and their annotated locations for NP_032404.1

      Status: VALIDATED

      Source sequence(s)
      AC131672, AK138136, BM899561, CJ056911
      Consensus CDS
      CCDS29068.1
      UniProtKB/Swiss-Prot
      O55091, Q3UUR6, Q9EQH0
      Related
      ENSMUSP00000025290.6, ENSMUST00000025290.7
      Conserved Domains (2) summary
      smart00591
      Location:15 → 115
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      pfam01205
      Location:181 → 288
      UPF0029; Uncharacterized protein family UPF0029

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      13087747..13126007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246850.3 → XP_011245152.1  protein IMPACT isoform X1

      See identical proteins and their annotated locations for XP_011245152.1

      Conserved Domains (2) summary
      smart00591
      Location:1 → 97
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      pfam01205
      Location:164 → 270
      UPF0029; Uncharacterized protein family UPF0029

    RNA

    1. XR_001782344.3 RNA Sequence

    2. XR_004939837.1 RNA Sequence