Sbno1 strawberry notch 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sbno1provided by MGI
Official Full Name: strawberry notch 1provided by MGI
Primary source: MGI:MGI:2384298
See related: Ensembl:ENSMUSG00000038095 AllianceGenome:MGI:2384298
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sno; Sbno; mSno1; 9330180L10Rik
Summary: Predicted to enable chromatin DNA binding activity and histone binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and liver. Orthologous to human SBNO1 (strawberry notch homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 13.5), testis adult (RPKM 12.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 63.54 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (124506765..124564059, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (124368702..124426007, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we performed Sbno1 gene knockdown in mice to study the effects of SBNO1 on neonatal testicular and spermatogonial stem cell development. Our results revealed that SBNO1 is required for neonatal testicular and SSC development in mice.
Title: Strawberry Notch 1 (SBNO1) promotes proliferation of spermatogonial stem cells via the noncanonical Wnt pathway in mice.
Sbno1 knockout embryos die at the preimplantation stage without forming a blastocoel, and Cdx2 is not turned on even though both Yap and Tead4 reside normally in nuclei.
Title: Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235319

AI849128 (e-PCR)
- UniSTS:179261

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein strawberry notch homolog 1

Names: sno, strawberry notch homolog 1; strawberry notch homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081203.2 → NP_001074672.1 protein strawberry notch homolog 1 isoform a

See identical proteins and their annotated locations for NP_001074672.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC127339

Consensus CDS

CCDS39280.1

UniProtKB/Swiss-Prot

Q3KQK3, Q689Z5, Q8BVN5

UniProtKB/TrEMBL

B2RRI2

Related

ENSMUSP00000066808.6, ENSMUST00000065263.12

Conserved Domains (2) summary

pfam13871
Location:870 → 1146

Helicase_C_4; C-terminal domain on Strawberry notch homolog

pfam13872
Location:257 → 559

AAA_34; P-loop containing NTP hydrolase pore-1
NM_001359978.1 → NP_001346907.1 protein strawberry notch homolog 1 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC127339

Consensus CDS

CCDS39280.1

UniProtKB/Swiss-Prot

Q3KQK3, Q689Z5, Q8BVN5

UniProtKB/TrEMBL

B2RRI2

Related

ENSMUSP00000142481.2, ENSMUST00000199808.5

Conserved Domains (2) summary

pfam13871
Location:870 → 1146

Helicase_C_4; C-terminal domain on Strawberry notch homolog

pfam13872
Location:257 → 559

AAA_34; P-loop containing NTP hydrolase pore-1
NM_001359979.1 → NP_001346908.1 protein strawberry notch homolog 1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a.

Source sequence(s)

AC127339

UniProtKB/Swiss-Prot

Q3KQK3, Q689Z5, Q8BVN5

UniProtKB/TrEMBL

F7CVW0

Conserved Domains (2) summary

pfam13871
Location:869 → 1145

Helicase_C_4; C-terminal domain on Strawberry notch homolog

pfam13872
Location:256 → 558

AAA_34; P-loop containing NTP hydrolase pore-1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

124506765..124564059 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165129.1 → XP_036021022.1 protein strawberry notch homolog 1 isoform X2

UniProtKB/Swiss-Prot

Q3KQK3, Q689Z5, Q8BVN5

UniProtKB/TrEMBL

F7CVW0

Related

ENSMUSP00000130860.3, ENSMUST00000168651.6

Conserved Domains (2) summary

pfam13871
Location:869 → 1145

Helicase_C_4; C-terminal domain on Strawberry notch homolog

pfam13872
Location:256 → 558

AAA_34; P-loop containing NTP hydrolase pore-1
XM_006530320.5 → XP_006530383.1 protein strawberry notch homolog 1 isoform X3

See identical proteins and their annotated locations for XP_006530383.1

UniProtKB/Swiss-Prot

Q3KQK3, Q689Z5, Q8BVN5

Conserved Domains (2) summary

pfam13871
Location:835 → 1111

Helicase_C_4; C-terminal domain on Strawberry notch homolog

pfam13872
Location:222 → 524

AAA_34; P-loop containing NTP hydrolase pore-1
XM_006530321.4 → XP_006530384.1 protein strawberry notch homolog 1 isoform X3

See identical proteins and their annotated locations for XP_006530384.1

UniProtKB/Swiss-Prot

Q3KQK3, Q689Z5, Q8BVN5

Conserved Domains (2) summary

pfam13871
Location:835 → 1111

Helicase_C_4; C-terminal domain on Strawberry notch homolog

pfam13872
Location:222 → 524

AAA_34; P-loop containing NTP hydrolase pore-1
XM_006530323.4 → XP_006530386.1 protein strawberry notch homolog 1 isoform X4

See identical proteins and their annotated locations for XP_006530386.1

UniProtKB/Swiss-Prot

Q3KQK3, Q689Z5, Q8BVN5

Conserved Domains (2) summary

pfam13871
Location:834 → 1110

Helicase_C_4; C-terminal domain on Strawberry notch homolog

pfam13872
Location:221 → 523

AAA_34; P-loop containing NTP hydrolase pore-1
XM_006530322.5 → XP_006530385.1 protein strawberry notch homolog 1 isoform X4

See identical proteins and their annotated locations for XP_006530385.1

UniProtKB/Swiss-Prot

Q3KQK3, Q689Z5, Q8BVN5

Conserved Domains (2) summary

pfam13871
Location:834 → 1110

Helicase_C_4; C-terminal domain on Strawberry notch homolog

pfam13872
Location:221 → 523

AAA_34; P-loop containing NTP hydrolase pore-1
XM_036165130.1 → XP_036021023.1 protein strawberry notch homolog 1 isoform X2

UniProtKB/Swiss-Prot

Q3KQK3, Q689Z5, Q8BVN5

UniProtKB/TrEMBL

F7CVW0

Conserved Domains (2) summary

pfam13871
Location:869 → 1145

Helicase_C_4; C-terminal domain on Strawberry notch homolog

pfam13872
Location:256 → 558

AAA_34; P-loop containing NTP hydrolase pore-1
XM_006530318.4 → XP_006530381.1 protein strawberry notch homolog 1 isoform X1

See identical proteins and their annotated locations for XP_006530381.1

UniProtKB/Swiss-Prot

Q3KQK3, Q689Z5, Q8BVN5

UniProtKB/TrEMBL

B2RRI2

Conserved Domains (2) summary

pfam13871
Location:870 → 1146

Helicase_C_4; C-terminal domain on Strawberry notch homolog

pfam13872
Location:257 → 559

AAA_34; P-loop containing NTP hydrolase pore-1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_145631.1: Suppressed sequence

Description

NM_145631.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.