Arg1 arginase, liver [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arg1provided by MGI
Official Full Name: arginase, liverprovided by MGI
Primary source: MGI:MGI:88070
See related: Ensembl:ENSMUSG00000019987 AllianceGenome:MGI:88070
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AI; PGIF; Arg-1
Summary: Enables arginase activity. Involved in defense response to protozoan; negative regulation of T-helper 2 cell cytokine production; and negative regulation of activated T cell proliferation. Acts upstream of or within response to nematode. Predicted to be located in extracellular space; mitochondrial outer membrane; and neuronal cell body. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study hyperargininemia. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 207.8) and liver E18 (RPKM 196.5) See more
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 12.26 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (24791105..24803368, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (24915207..24927470, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Potential i-Nos/Arg-1 Switch with NLRP3 and Parasitic Load Down Regulation in Experimental Schistosoma mansoni Infection via Chloroquine Repurposing.
Title: Potential i-Nos/Arg-1 Switch with NLRP3 and Parasitic Load Down Regulation in Experimental Schistosoma mansoni Infection via Chloroquine Repurposing.
Arginase 1 does not affect RNA m6A methylation in mouse fetal lung.
Title: Arginase 1 does not affect RNA m6A methylation in mouse fetal lung.
DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression.
Title: DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression.
Methylglyoxal-Modified Albumin Effects on Endothelial Arginase Enzyme and Vascular Function.
Title: Methylglyoxal-Modified Albumin Effects on Endothelial Arginase Enzyme and Vascular Function.
Arginase-1 promotes lens epithelial-to-mesenchymal transition in different models of anterior subcapsular cataract.
Title: Arginase-1 promotes lens epithelial-to-mesenchymal transition in different models of anterior subcapsular cataract.
Loss of CD4[+] T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection.
Title: Loss of CD4(+) T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection.
Inhibitory IL-10-producing CD4[+] T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1.
Title: Inhibitory IL-10-producing CD4(+) T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1.
Arginase 1 and L-arginine coordinate fetal lung development and the initiation of labor in mice.
Title: Arginase 1 and L-arginine coordinate fetal lung development and the initiation of labor in mice.
Arginase 1 is a key driver of immune suppression in pancreatic cancer.
Title: Arginase 1 is a key driver of immune suppression in pancreatic cancer.
ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain.
Title: ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain.

Submit: New GeneRIF Correction See all GeneRIFs (148)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Arg1 (e-PCR), detects polymorphism
- UniSTS:516127

AI256583 (e-PCR)
- UniSTS:180017

Arg1 (e-PCR), detects polymorphism
- UniSTS:141121

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arginase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arginase activity	IDA Inferred from Direct Assay more info	PubMed
enables arginase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in arginine catabolic process to ornithine	IBA Inferred from Biological aspect of Ancestor more info
involved_in arginine catabolic process to ornithine	ISO Inferred from Sequence Orthology more info
involved_in arginine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in arginine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in defense response to protozoan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T-helper 2 cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type II interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type II interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil mediated killing of fungus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neutrophil mediated killing of fungus	ISO Inferred from Sequence Orthology more info
involved_in regulation of L-arginine import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to nematode	IDA Inferred from Direct Assay more info	PubMed
involved_in urea cycle	IEA Inferred from Electronic Annotation more info
involved_in urea cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: arginase-1

Names: arginase 1, liver; arginase I; liver-type arginase; type I arginase

NP_031508.1

EC 3.5.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.