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    Gmip Gem-interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 78816, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gmipprovided by MGI
    Official Full Name
    Gem-interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1926066
    See related
    Ensembl:ENSMUSG00000036246 AllianceGenome:MGI:1926066
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5031419I10Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in intracellular signal transduction; negative regulation of GTPase activity; and negative regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in brain; gonad; and thyroid gland. Orthologous to human GMIP (GEM interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 38.0), thymus adult (RPKM 25.8) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gmip in Genome Data Viewer
    Location:
    8 B3.3; 8 33.88 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70260912..70274520)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69808298..69821870)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 866 Neighboring gene STARR-positive B cell enhancer ABC_E6643 Neighboring gene STARR-positive B cell enhancer ABC_E6644 Neighboring gene ATPase type 13A1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:72332338-72332525 Neighboring gene predicted gene, 33695 Neighboring gene STARR-positive B cell enhancer ABC_E2867 Neighboring gene lysophosphatidic acid receptor 2 Neighboring gene pre B cell leukemia homeobox 4 Neighboring gene STARR-seq mESC enhancer starr_21749

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Speed control for neuronal migration in the postnatal brain by Gmip-mediated local inactivation of RhoA. Ota H, et al. Nat Commun, 2014 Jul 30. PMID 25074242
    2. Gene expression analysis of the late embryonic mouse cerebral cortex using DNA microarray: identification of several region- and layer-specific genes. Funatsu N, et al. Cereb Cortex, 2004 Sep. PMID 15142957
    3. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747
    4. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GEM-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198101.1 → NP_932769.1  GEM-interacting protein

      See identical proteins and their annotated locations for NP_932769.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057037
      Consensus CDS
      CCDS22350.1
      UniProtKB/Swiss-Prot
      Q6P9S3, Q6PGG2
      Related
      ENSMUSP00000045676.9, ENSMUST00000036074.15
      Conserved Domains (4) summary
      TIGR02473
      Location:87 → 217
      flagell_FliJ; flagellar export protein FliJ
      smart00109
      Location:491 → 536
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:548 → 751
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:112 → 312
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70260912..70274520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509799.5 → XP_006509862.1  GEM-interacting protein isoform X6

      Conserved Domains (3) summary
      smart00109
      Location:595 → 640
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:652 → 732
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:216 → 416
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_030243857.2 → XP_030099717.2  GEM-interacting protein isoform X4

      Related
      ENSMUSP00000116542.2, ENSMUST00000123453.2
      Conserved Domains (3) summary
      cd04408
      Location:652 → 855
      RhoGAP_GMIP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase ...
      cd20816
      Location:595 → 644
      C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family
      cl12013
      Location:216 → 416
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_006509797.5 → XP_006509860.2  GEM-interacting protein isoform X1

      Conserved Domains (3) summary
      smart00109
      Location:491 → 536
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:548 → 751
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:112 → 312
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. XM_006509798.5 → XP_006509861.2  GEM-interacting protein isoform X3

      Conserved Domains (3) summary
      smart00109
      Location:491 → 536
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd04408
      Location:548 → 751
      RhoGAP_GMIP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase ...
      cl12013
      Location:112 → 312
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. XM_036154385.1 → XP_036010278.1  GEM-interacting protein isoform X5

      Conserved Domains (3) summary
      cd20816
      Location:358 → 407
      C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family
      cl02570
      Location:415 → 618
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:58 → 179
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. XM_036154386.1 → XP_036010279.1  GEM-interacting protein isoform X5

      Conserved Domains (3) summary
      cd20816
      Location:358 → 407
      C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family
      cl02570
      Location:415 → 618
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:58 → 179
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    7. XM_030243856.2 → XP_030099716.1  GEM-interacting protein isoform X2

      Conserved Domains (3) summary
      smart00109
      Location:503 → 548
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:560 → 763
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:124 → 324
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_003947356.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PGG2.1 GenPept UniProtKB/Swiss-Prot:Q6PGG2

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