Acot1 acyl-CoA thioesterase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acot1provided by MGI
Official Full Name: acyl-CoA thioesterase 1provided by MGI
Primary source: MGI:MGI:1349396
See related: Ensembl:ENSMUSG00000072949 AllianceGenome:MGI:1349396
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ACH2; Cte1; CTE-1; CTE-I; D12Ucla1
Summary: Enables fatty acyl-CoA hydrolase activity. Acts upstream of or within long-chain fatty acid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ACOT1 (acyl-CoA thioesterase 1) and ACOT2 (acyl-CoA thioesterase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E18 (RPKM 44.5), kidney adult (RPKM 41.4) and 26 other tissues See more
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Genomic context

Location:: 12 D1; 12 39.0 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (84056276..84064444)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (84009502..84017670)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACOT1 deficiency attenuates high-fat diet-induced fat mass gain by increasing energy expenditure.
Title: ACOT1 deficiency attenuates high-fat diet-induced fat mass gain by increasing energy expenditure.
These results suggest that ACOT1 has potential therapeutic values to protect heart from sepsis mediated dysfunction, possibly through activating PPARa/PGC1a signaling.
Title: Cardiomyocyte specific expression of Acyl-coA thioesterase 1 attenuates sepsis induced cardiac dysfunction and mortality.
ACOT1 plays a crucial protective role in the diabetic heart via PPARalpha/PGC1alpha signaling.
Title: Protective effects of Acyl-coA thioesterase 1 on diabetic heart via PPARα/PGC1α signaling.
Data show that Acot1 is under regulation by an interplay between hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha.
Title: The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1)

General gene information

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Markers

Acot1 (e-PCR), detects polymorphism
- UniSTS:527234

Y14004 (e-PCR)
- UniSTS:160229

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables fatty acyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acyl-CoA hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables fatty acyl-CoA hydrolase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acyl-CoA metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within long-chain fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acyl-coenzyme A thioesterase 1

Names: acyl-CoA thioesterase 1, cytosolic; cytosolic acyl-CoA thioesterase 1; inducible cytosolic acyl-coenzyme A thioester hydrolase; long chain acyl-CoA hydrolase; long chain acyl-CoA thioester hydrolase; palmitoyl-coenzyme A thioesterase

NP_036136.1

EC 3.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012006.2 → NP_036136.1 acyl-coenzyme A thioesterase 1

See identical proteins and their annotated locations for NP_036136.1

Status: PROVISIONAL

Source sequence(s)

AC133183

Consensus CDS

CCDS36487.1

UniProtKB/Swiss-Prot

O55137, Q549A9

UniProtKB/TrEMBL

Q99L15

Related

ENSMUSP00000126448.2, ENSMUST00000168120.3

Conserved Domains (3) summary

pfam08840
Location:204 → 410

BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

pfam04775
Location:16 → 137

Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

cl21494
Location:145 → 257

Abhydrolase; alpha/beta hydrolases