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    Bcat1 branched chain aminotransferase 1, cytosolic [ Mus musculus (house mouse) ]

    Gene ID: 12035, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Bcat1provided by MGI
    Official Full Name
    branched chain aminotransferase 1, cytosolicprovided by MGI
    Primary source
    MGI:MGI:104861
    See related
    Ensembl:ENSMUSG00000030268 AllianceGenome:MGI:104861
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BCATc; Eca39
    Summary
    Enables branched-chain-amino-acid transaminase activity. Acts upstream of or within branched-chain amino acid catabolic process. Located in cytosol. Is expressed in several structures, including alimentary system; craniocervical region bone; limb; nervous system; and sensory organ. Orthologous to human BCAT1 (branched chain amino acid transaminase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 2.3), ovary adult (RPKM 2.1) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bcat1 in Genome Data Viewer
    Location:
    6 G3; 6 77.27 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (144939561..145021883, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (144993835..145076157, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32124 Neighboring gene STARR-positive B cell enhancer mm9_chr6:144788652-144788953 Neighboring gene STARR-seq mESC enhancer starr_17760 Neighboring gene predicted gene, 20124 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:144851216-144851325 Neighboring gene STARR-positive B cell enhancer ABC_E10418 Neighboring gene STARR-seq mESC enhancer starr_17761 Neighboring gene predicted gene, 53314 Neighboring gene predicted gene, 46721 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:144969219-144969382 Neighboring gene STARR-seq mESC enhancer starr_17771 Neighboring gene STARR-positive B cell enhancer ABC_E11339 Neighboring gene STARR-seq mESC enhancer starr_17772 Neighboring gene predicted gene, 26666 Neighboring gene STARR-positive B cell enhancer ABC_E8147 Neighboring gene predicted gene, 38925 Neighboring gene STARR-seq mESC enhancer starr_17775 Neighboring gene STARR-seq mESC enhancer starr_17776 Neighboring gene STARR-positive B cell enhancer ABC_E2809 Neighboring gene STARR-positive B cell enhancer mm9_chr6:145072197-145072498 Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E4880 Neighboring gene predicted gene 15543 Neighboring gene dynein axonemal intermediate chain 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice deficient in the mitochondrial branched-chain aminotransferase (BCATm) respond with delayed tumour growth to a challenge with EL-4 lymphoma. Ananieva EA, et al. Br J Cancer, 2018 Oct. PMID 30318512, Free PMC Article
    2. Transamination is required for {alpha}-ketoisocaproate but not leucine to stimulate insulin secretion. Zhou Y, et al. J Biol Chem, 2010 Oct 29. PMID 20736162, Free PMC Article
    3. Expression of cytosolic branched chain aminotransferase (BCATc) mRNA in the developing mouse brain. Castellano S, et al. Gene Expr Patterns, 2007 Feb. PMID 17150414
    4. Cytosolic branched chain aminotransferase (BCATc) mRNA is up-regulated in restricted brain areas of BDNF transgenic mice. Castellano S, et al. Brain Res, 2006 Sep 7. PMID 16828066
    5. Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4+ T cells. Ananieva EA, et al. J Biol Chem, 2014 Jul 4. PMID 24847056, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
      Title: HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
    2. Bcat1 is controlled by Tsc2/mTORC1 pathway at expression levels and its deficiency together with Bcat2 inactivation suppresses the growth of a Tsc2[-/-] tumor cell line.
      Title: Bcat1 is controlled by Tsc2/mTORC1 pathway at expression levels and its deficiency together with Bcat2 inactivation suppresses the growth of a Tsc2(-/-) tumor cell line.
    3. BCAT1 redox function maintains mitotic fidelity.
      Title: BCAT1 redox function maintains mitotic fidelity.
    4. The proatherosclerotic function of BCAT1 in atherosclerosis development of aged-apolipoprotein E-deficient mice.
      Title: The proatherosclerotic function of BCAT1 in atherosclerosis development of aged-apolipoprotein E-deficient mice.
    5. BCAT1 promotes osteoclast maturation by regulating branched-chain amino acid metabolism.
      Title: BCAT1 promotes osteoclast maturation by regulating branched-chain amino acid metabolism.
    6. Impaired expression of BCAT1 relates to muscle atrophy of mouse model of sarcopenia.
      Title: Impaired expression of BCAT1 relates to muscle atrophy of mouse model of sarcopenia.
    7. Branched-chain amino acid aminotransferase-1 regulates self-renewal and pluripotency of mouse embryonic stem cells through Ras signaling.
      Title: Branched-chain amino acid aminotransferase-1 regulates self-renewal and pluripotency of mouse embryonic stem cells through Ras signaling.
    8. BCAT1 binds the RNA-binding protein ZNF423 to activate autophagy via the IRE1-XBP-1-RIDD axis in hypoxic PASMCs.
      Title: BCAT1 binds the RNA-binding protein ZNF423 to activate autophagy via the IRE1-XBP-1-RIDD axis in hypoxic PASMCs.
    9. Global deletion of BCATm caused a dramatic build-up of branched-chain amino acids, which could not be utilised for energy or amino acid synthesis, ultimately delaying the growth of lymphoma tumours.
      Title: Mice deficient in the mitochondrial branched-chain aminotransferase (BCATm) respond with delayed tumour growth to a challenge with EL-4 lymphoma.
    10. regulatory role in macrophage function
      Title: BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-isoleucine-2-oxoglutarate transaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables L-leucine-2-oxoglutarate transaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables L-valine-2-oxoglutarate transaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables branched-chain-amino-acid transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables branched-chain-amino-acid transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables branched-chain-amino-acid transaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-leucine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-valine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in branched-chain amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within branched-chain amino acid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    branched-chain-amino-acid aminotransferase, cytosolic
    Names
    BCAT(c)
    NP_001019639.1
    NP_031558.3
    XP_011239868.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024468.3 → NP_001019639.1  branched-chain-amino-acid aminotransferase, cytosolic isoform 1

      See identical proteins and their annotated locations for NP_001019639.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC140416, AK036309, AW491045
      Consensus CDS
      CCDS20691.1
      UniProtKB/TrEMBL
      Q8CBC8, Q9CXX6
      Related
      ENSMUSP00000032402.6, ENSMUST00000032402.12
      Conserved Domains (2) summary
      PRK13357
      Location:100 → 453
      PRK13357; branched-chain amino acid aminotransferase; Provisional
      cd01557
      Location:148 → 442
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

    2. NM_007532.5 → NP_031558.3  branched-chain-amino-acid aminotransferase, cytosolic isoform 2

      See identical proteins and their annotated locations for NP_031558.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, compared to variant 1. The resulting protein (isoform 2) has a shorter and unique N-terminus, compared to isoform 1.
      Source sequence(s)
      AC140416, AK167232, AW491045, BY781109
      Consensus CDS
      CCDS39703.1
      UniProtKB/Swiss-Prot
      P24288, Q7TMT2
      UniProtKB/TrEMBL
      Q3TJN1, Q9CXX6
      Related
      ENSMUSP00000107371.2, ENSMUST00000111742.8
      Conserved Domains (2) summary
      PRK13357
      Location:33 → 386
      PRK13357; branched-chain amino acid aminotransferase; Provisional
      cd01557
      Location:81 → 375
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      144939561..145021883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241566.3 → XP_011239868.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X1

      UniProtKB/TrEMBL
      Q9CXX6
      Conserved Domains (1) summary
      PRK13357
      Location:32 → 385
      PRK13357; branched-chain amino acid aminotransferase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24288.2 GenPept UniProtKB/Swiss-Prot:P24288

    Gene LinkOut

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