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    RNF145 ring finger protein 145 [ Homo sapiens (human) ]

    Gene ID: 153830, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RNF145provided by HGNC
    Official Full Name
    ring finger protein 145provided by HGNC
    Primary source
    HGNC:HGNC:20853
    See related
    Ensembl:ENSG00000145860 MIM:620640; AllianceGenome:HGNC:20853
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endomembrane system. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung (RPKM 33.4), gall bladder (RPKM 23.7) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RNF145 in Genome Data Viewer
    Location:
    5q33.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (159157409..159210053, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (159686225..159738515, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (158584417..158637061, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr5:158124779-158125433 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:158139245-158139745 Neighboring gene VISTA enhancer hs813 Neighboring gene NANOG hESC enhancer GRCh37_chr5:158164501-158165077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16566 Neighboring gene EBF transcription factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23536 Neighboring gene VISTA enhancer hs230 Neighboring gene NANOG hESC enhancer GRCh37_chr5:158378905-158379562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23537 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:158384828-158385690 Neighboring gene NANOG hESC enhancer GRCh37_chr5:158403034-158403551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16567 Neighboring gene VISTA enhancer hs1022 Neighboring gene VISTA enhancer hs1117 Neighboring gene VISTA enhancer hs1123 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:158522773-158523666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:158524561-158525454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16568 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:158527833-158528459 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:158527204-158527832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:158531040-158531945 Neighboring gene uncharacterized LOC107986467 Neighboring gene long intergenic non-protein coding RNA 2202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23540 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:158588140-158589339 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:158634672-158635327 Neighboring gene uncharacterized LOC107986468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23544 Neighboring gene small nucleolar RNA SNORA68 Neighboring gene long intergenic non-protein coding RNA 1932 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:158689523-158690030 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:158690031-158690538 Neighboring gene ubiquitin like domain containing CTD phosphatase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China. Ming J, et al. Sci Rep, 2021 Mar 16. PMID 33727652, Free PMC Article
    2. CircZDBF2 up-regulates RNF145 by ceRNA model and recruits CEBPB to accelerate oral squamous cell carcinoma progression via NFκB signaling pathway. Rong L, et al. J Transl Med, 2022 Apr 1. PMID 35365168, Free PMC Article
    3. Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase. Jiang LY, et al. J Biol Chem, 2018 Mar 16. PMID 29374057, Free PMC Article
    4. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Soranzo N, et al. Nat Genet, 2009 Nov. PMID 19820697, Free PMC Article
    5. MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment. Kumar S, et al. Cell Rep, 2019 Feb 12. PMID 30759391, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircZDBF2 up-regulates RNF145 by ceRNA model and recruits CEBPB to accelerate oral squamous cell carcinoma progression via NFkappaB signaling pathway.
      Title: CircZDBF2 up-regulates RNF145 by ceRNA model and recruits CEBPB to accelerate oral squamous cell carcinoma progression via NFκB signaling pathway.
    2. Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China.
      Title: Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
    EBI GWAS Catalog
    New gene functions in megakaryopoiesis and platelet formation.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31951, FLJ44310, DKFZp686M11215

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein 145
    NP_001186309.1
    NP_001186310.1
    NP_001186311.1
    NP_001186312.1
    NP_653327.1
    XP_016864627.1
    XP_024310151.1
    XP_054207831.1
    XP_054207832.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199380.2 → NP_001186309.1  RING finger protein 145 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK308394, AL831829, BC042684
      Consensus CDS
      CCDS56393.1
      UniProtKB/TrEMBL
      A8K9Y9
      Related
      ENSP00000430955.1, ENST00000518802.5
      Conserved Domains (3) summary
      pfam12678
      Location:564 → 605
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:565 → 605
      zf-RING_2; Ring finger domain
      pfam13705
      Location:38 → 536
      TRC8_N; TRC8 N-terminal domain

    2. NM_001199381.2 → NP_001186310.1  RING finger protein 145 isoform 3

      See identical proteins and their annotated locations for NP_001186310.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 5' exon, as compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK304435, AL697229, AL831829
      Consensus CDS
      CCDS56392.1
      UniProtKB/TrEMBL
      A8K9Y9
      Related
      ENSP00000430753.2, ENST00000521606.6
      Conserved Domains (3) summary
      pfam12678
      Location:551 → 592
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:552 → 592
      zf-RING_2; Ring finger domain
      pfam13705
      Location:25 → 523
      TRC8_N; TRC8 N-terminal domain

    3. NM_001199382.2 → NP_001186311.1  RING finger protein 145 isoform 4

      See identical proteins and their annotated locations for NP_001186311.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate 5' exon, as compared to variant 1. The resulting isoform (4) lacks a segment in the N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK304228, AL831829, BC042684, DC418555
      Consensus CDS
      CCDS56391.1
      UniProtKB/TrEMBL
      A8K9Y9
      Related
      ENSP00000429071.1, ENST00000520638.1
      Conserved Domains (3) summary
      pfam12678
      Location:548 → 589
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:549 → 589
      zf-RING_2; Ring finger domain
      pfam13705
      Location:22 → 520
      TRC8_N; TRC8 N-terminal domain

    4. NM_001199383.2 → NP_001186312.1  RING finger protein 145 isoform 5

      See identical proteins and their annotated locations for NP_001186312.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate 5' exon, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (5) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK292854, AL831829, CK821118
      Consensus CDS
      CCDS56390.1
      UniProtKB/Swiss-Prot
      B7Z903, B7Z949, E7EVI7, Q8IVP7, Q96MT1
      UniProtKB/TrEMBL
      A8K9Y9
      Related
      ENSP00000409064.2, ENST00000424310.7
      Conserved Domains (3) summary
      pfam12678
      Location:534 → 575
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:535 → 575
      zf-RING_2; Ring finger domain
      pfam13705
      Location:8 → 506
      TRC8_N; TRC8 N-terminal domain

    5. NM_144726.3 → NP_653327.1  RING finger protein 145 isoform 2

      See identical proteins and their annotated locations for NP_653327.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK056513, AL831829, BC042684
      Consensus CDS
      CCDS4344.1
      UniProtKB/TrEMBL
      A8K9Y9
      Related
      ENSP00000274542.2, ENST00000274542.6
      Conserved Domains (3) summary
      pfam12678
      Location:562 → 603
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:563 → 603
      zf-RING_2; Ring finger domain
      pfam13705
      Location:36 → 534
      TRC8_N; TRC8 N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      159157409..159210053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009138.3 → XP_016864627.1  RING finger protein 145 isoform X2

      UniProtKB/Swiss-Prot
      B7Z903, B7Z949, E7EVI7, Q8IVP7, Q96MT1
      UniProtKB/TrEMBL
      A8K9Y9
      Conserved Domains (3) summary
      pfam12678
      Location:534 → 575
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:535 → 575
      zf-RING_2; Ring finger domain
      pfam13705
      Location:8 → 506
      TRC8_N; TRC8 N-terminal domain

    2. XM_024454383.2 → XP_024310151.1  RING finger protein 145 isoform X1

      UniProtKB/TrEMBL
      A8K9Y9
      Conserved Domains (3) summary
      pfam13705
      Location:24 → 522
      TRC8_N; TRC8 N-terminal domain
      cd16684
      Location:549 → 591
      RING-H2_RNF145; RING finger, H2 subclass, found in RING finger protein 145 (RNF145) and similar proteins
      cl26329
      Location:536 → 641
      zf-rbx1; RING-H2 zinc finger domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      159686225..159738515 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351857.1 → XP_054207832.1  RING finger protein 145 isoform X2

      UniProtKB/Swiss-Prot
      B7Z903, B7Z949, E7EVI7, Q8IVP7, Q96MT1
      UniProtKB/TrEMBL
      A8K9Y9

    2. XM_054351856.1 → XP_054207831.1  RING finger protein 145 isoform X1

      UniProtKB/TrEMBL
      A8K9Y9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96MT1.2 GenPept UniProtKB/Swiss-Prot:Q96MT1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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