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    CG14641 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40529, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14641provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037220
    Locus tag
    Dmel_CG14641
    See related
    AllianceGenome:FB:FBgn0037220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg14641; Dmel\CG14641
    Summary
    Predicted to enable U6 snRNA binding activity; mRNA binding activity; and pre-mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; mesoderm; and posterior endoderm. Orthologous to human RBM22 (RNA binding motif protein 22). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14641 in Genome Data Viewer
    Location:
    82A1-82A1; 3-47.1 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4230779..4232342, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (56501..58064, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene auxilin Neighboring gene uncharacterized protein Neighboring gene Dihydropterin deaminase Neighboring gene antisense RNA:CR46255 Neighboring gene abstrakt Neighboring gene Gelsolin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development. Guilgur LG, et al. Elife, 2014 Apr 22. PMID 24755291, Free PMC Article
    2. Drosophila genome-wide RNAi screen identifies multiple regulators of HIF-dependent transcription in hypoxia. Dekanty A, et al. PLoS Genet, 2010 Jun 24. PMID 20585616, Free PMC Article
    3. A functional genomic screen for cardiogenic genes using RNA interference in developing Drosophila embryos. Kim YO, et al. Proc Natl Acad Sci U S A, 2004 Jan 6. PMID 14684833, Free PMC Article
    4. Identification of alternative splicing regulators by RNA interference in Drosophila. Park JW, et al. Proc Natl Acad Sci U S A, 2004 Nov 9. PMID 15492211, Free PMC Article
    5. Sex-specific expression of alternative transcripts in Drosophila. McIntyre LM, et al. Genome Biol, 2006. PMID 16934145, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U6 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    Component Evidence Code Pubs
    part_of Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type catalytic step 1 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14641-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4230779..4232342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141183.4 → NP_649440.3  uncharacterized protein Dmel_CG14641 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649440.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RB1, Q9VMZ0
      Related
      FBpp0078624
      Conserved Domains (3) summary
      smart00356
      Location:159 → 185
      ZnF_C3H1; zinc finger
      COG0724
      Location:186 → 309
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12224
      Location:231 → 304
      RRM_RBM22; RNA recognition motif (RRM) found in Pre-mRNA-splicing factor RBM22 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95RB1 Q95RB1

    Gene LinkOut

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