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    CG10814 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36481, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10814provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033830
    Locus tag
    Dmel_CG10814
    See related
    AllianceGenome:FB:FBgn0033830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    dGBBD; Dmel\CG10814; gamma-BBH
    Summary
    Predicted to enable gamma-butyrobetaine dioxygenase activity. Predicted to be involved in carnitine biosynthetic process. Predicted to be active in mitochondrion. Orthologous to human BBOX1 (gamma-butyrobetaine hydroxylase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10814 in Genome Data Viewer
    Location:
    50A3-50A3; 2-68 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13375975..13377731, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9263480..9265236, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45312 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Attacin-C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genes Related to Fatty Acid β-Oxidation Play a Role in the Functional Decline of the Drosophila Brain with Age. Laranjeira A, et al. PLoS One, 2016. PMID 27518101, Free PMC Article
    2. The Reversible Carnitine Palmitoyltransferase 1 Inhibitor (Teglicar) Ameliorates the Neurodegenerative Phenotype in a Drosophila Huntington's Disease Model by Acting on the Expression of Carnitine-Related Genes. Bertapelle C, et al. Molecules, 2022 May 13. PMID 35630602, Free PMC Article
    3. Mixture modeling of transcript abundance classes in natural populations. Hsieh WP, et al. Genome Biol, 2007. PMID 17547747, Free PMC Article
    4. L-Carnitine in Drosophila: A Review. Carillo MR, et al. Antioxidants (Basel), 2020 Dec 21. PMID 33371457, Free PMC Article
    5. Quercetin ameliorates Aβ toxicity in Drosophila AD model by modulating cell cycle-related protein expression. Kong Y, et al. Oncotarget, 2016 Oct 18. PMID 27626494, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables gamma-butyrobetaine dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carnitine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10814-PA
    Gamma-Butyrobetaine dioxygenase
    gamma-ButyroBetaine hydroxylase
    NP_610868.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13375975..13377731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137024.3 → NP_610868.1  uncharacterized protein Dmel_CG10814 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610868.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4A8
      Related
      FBpp0086837
      Conserved Domains (3) summary
      cd00250
      Location:119 → 387
      CAS_like; Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases ...
      TIGR02409
      Location:27 → 398
      carnitine_bodg; gamma-butyrobetaine hydroxylase
      pfam06155
      Location:22 → 106
      DUF971; Protein of unknown function (DUF971)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K4A8 Q7K4A8

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