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    CG1233 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38063, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG1233provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035137
    Locus tag
    Dmel_CG1233
    See related
    AllianceGenome:FB:FBgn0035137
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG1233
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to human ZNF316 (zinc finger protein 316) and ZNF787 (zinc finger protein 787). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1233 in Genome Data Viewer
    Location:
    61C1-61C1; 3-0.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (361472..365681)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (361472..365681)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Regulator of cullins 1b Neighboring gene Cell division cycle 5 Neighboring gene uncharacterized protein Neighboring gene trachealess Neighboring gene long non-coding RNA:CR45378 Neighboring gene long non-coding RNA:CR43969

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila genetic screen for suppressors of S6kinase-dependent growth identifies the F-box subunit Archipelago/FBXW7. Zahoor MK, et al. Mol Genet Genomics, 2019 Jun. PMID 30656413
    2. Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets. Rehwinkel J, et al. RNA, 2005 Oct. PMID 16199763, Free PMC Article
    3. A Comprehensive Drosophila melanogaster Transcription Factor Interactome. Shokri L, et al. Cell Rep, 2019 Apr 16. PMID 30995488, Free PMC Article
    4. A large-scale, in vivo transcription factor screen defines bivalent chromatin as a key property of regulatory factors mediating Drosophila wing development. Schertel C, et al. Genome Res, 2015 Apr. PMID 25568052, Free PMC Article
    5. Transcription factor networks in Drosophila melanogaster. Rhee DY, et al. Cell Rep, 2014 Sep 25. PMID 25242320, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1233-PA
    CG1233-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      361472..365681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167833.2 → NP_728528.1  uncharacterized protein Dmel_CG1233, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728528.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0Q9
      Related
      FBpp0072448
      Conserved Domains (5) summary
      COG1594
      Location:778 → 873
      RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]
      sd00017
      Location:702 → 722
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:700 → 722
      zf-C2H2; Zinc finger, C2H2 type
      pfam12756
      Location:705 → 811
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
      pfam13465
      Location:687 → 711
      zf-H2C2_2; Zinc-finger double domain

    2. NM_138190.2 → NP_612034.1  uncharacterized protein Dmel_CG1233, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612034.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NP52, Q9I7U7
      Related
      FBpp0072447
      Conserved Domains (5) summary
      COG1594
      Location:966 → 1061
      RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]
      sd00017
      Location:890 → 910
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:888 → 910
      zf-C2H2; Zinc finger, C2H2 type
      pfam12756
      Location:893 → 999
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
      pfam13465
      Location:875 → 899
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I7U7 Q9I7U7
    Q9W0Q9 Q9W0Q9

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