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    rgr regular [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35843, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rgrprovided by FlyBase
    Official Full Name
    regularprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267792
    Locus tag
    Dmel_CG8643
    See related
    AllianceGenome:FB:FBgn0267792
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14751; CG8643; Dmel\CG8643; l(2)k02605
    Summary
    Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic/larval posterior spiracle; mesoderm; and pole plasm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rgr in Genome Data Viewer
    Location:
    44D4-44D4; 2-59 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8600415..8612295)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4487920..4499800)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Lunapark Neighboring gene uncharacterized protein Neighboring gene Calcium-independent receptor for alpha-latrotoxin Neighboring gene Vacuolar protein sorting 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A P element with a novel fusion of reporters identifies regular, a C2H2 zinc-finger gene downstream of the circadian clock. Scully AL, et al. Mol Cell Neurosci, 2002 Apr. PMID 11988018
    2. Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme. Terriente-Felix A, et al. Development, 2013 Feb. PMID 23325760, Free PMC Article
    3. Molecular characterization of teflon, a gene required for meiotic autosome segregation in male Drosophila melanogaster. Arya GH, et al. Genetics, 2006 Sep. PMID 16816414, Free PMC Article
    4. The Drosophila STAM gene homolog is in a tight gene cluster, and its expression correlates to that of the adjacent gene ial. Mesilaty-Gross S, et al. Gene, 1999 Apr 29. PMID 10231582
    5. The negative elongation factor NELF promotes induced transcriptional response of Drosophila ecdysone-dependent genes. Mazina MY, et al. Sci Rep, 2021 Jan 8. PMID 33420323, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regular
    Names
    CG8643-PA
    CG8643-PC
    lethal (2) k02605
    rgr-PA
    rgr-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8600415..8612295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169618.2 → NP_001163089.2  regular, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163089.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JH10
      Conserved Domains (4) summary
      COG5048
      Location:742 → 824
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:719 → 739
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam10545
      Location:335 → 420
      MADF_DNA_bdg; Alcohol dehydrogenase transcription factor Myb/SANT-like
      pfam13465
      Location:763 → 784
      zf-H2C2_2; Zinc-finger double domain

    2. NM_165611.3 → NP_724690.1  regular, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724690.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KG36
      Related
      FBpp0087772
      Conserved Domains (4) summary
      COG5048
      Location:709 → 791
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:686 → 706
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam10545
      Location:302 → 387
      MADF_DNA_bdg; Alcohol dehydrogenase transcription factor Myb/SANT-like
      pfam13465
      Location:730 → 751
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JH10 E1JH10
    Q5U0W3 Q5U0W3
    Q7KG36 Q7KG36

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