U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Vps50 Vacuolar protein sorting 50 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37021, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Vps50provided by FlyBase
    Official Full Name
    Vacuolar protein sorting 50provided by FlyBase
    Primary source
    FLYBASE:FBgn0034271
    Locus tag
    Dmel_CG4996
    See related
    AllianceGenome:FB:FBgn0034271
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4996; Dmel\CG4996; Vps54L
    Summary
    Predicted to enable SNARE binding activity. Predicted to be involved in endocytic recycling. Located in endosome. Part of GARP complex. Orthologous to human VPS50 (VPS50 subunit of EARP/GARPII complex). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Vps50 in Genome Data Viewer
    Location:
    54E5-54E7; 2-84 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17739901..17743969)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13627406..13631474)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene hyccin Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class A Neighboring gene Ionotropic receptor 54a Neighboring gene subito Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling. O'Brien CE, et al. J Cell Biol, 2023 Jan 2. PMID 36239632, Free PMC Article
    2. Using the P[wHy] hybrid transposable element to disrupt genes in region 54D-55B in Drosophila melanogaster. Mohr SE, et al. Genetics, 2002 Sep. PMID 12242231, Free PMC Article
    3. Toward a comprehensive map of the effectors of rab GTPases. Gillingham AK, et al. Dev Cell, 2014 Nov 10. PMID 25453831, Free PMC Article
    4. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article
    5. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytic recycling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytic recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of EARP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EARP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of GARP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    vacuolar protein sorting 50
    Names
    CG4996-PA
    Vps50-PA
    vacuolar protein sorting 54L

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17739901..17743969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137414.3 → NP_611258.2  vacuolar protein sorting 50 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611258.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAY8, Q960B0
      Related
      FBpp0086024
      Conserved Domains (2) summary
      pfam10474
      Location:704 → 932
      DUF2451; Protein of unknown function C-terminus (DUF2451)
      pfam10475
      Location:75 → 362
      DUF2450; Protein of unknown function N-terminal domain (DUF2450)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAY8 A1ZAY8
    Q960B0 Q960B0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools