Grip163 Grip163 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Grip163provided by FlyBase
Official Full Name: Grip163provided by FlyBase
Primary source: FLYBASE:FBgn0026432
Locus tag: Dmel_CG5688
See related: AllianceGenome:FB:FBgn0026432
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5688; Dgrip163; DGrip163; Dgrips163; Dmel\CG5688; GCP6; grip163
Summary: Enables gamma-tubulin binding activity. Involved in mitotic cell cycle and mitotic spindle-templated microtubule nucleation. Located in centrosome. Part of gamma-tubulin ring complex. Is expressed in organism and spermatozoon. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 1. Orthologous to human TUBGCP6 (tubulin gamma complex component 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (11993274..11998138, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (11986374..11991238, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Function of this specific subunit of the ring complex was determined.
Title: Drosophila melanogaster gamma-TuRC is dispensable for targeting gamma-tubulin to the centrosome and microtubule nucleation.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables gamma-tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables gamma-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables gamma-tubulin binding	IEA Inferred from Electronic Annotation more info
contributes_to microtubule minus-end binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule nucleation	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle-templated microtubule nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in spindle assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
part_of gamma-tubulin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of gamma-tubulin ring complex	IDA Inferred from Direct Assay more info	PubMed
part_of gamma-tubulin ring complex	IPI Inferred from Physical Interaction more info	PubMed
part_of gamma-tubulin ring complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in microtubule organizing center	IEA Inferred from Electronic Annotation more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info

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