sesB stress-sensitive B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sesBprovided by FlyBase
Official Full Name: stress-sensitive Bprovided by FlyBase
Primary source: FLYBASE:FBgn0003360
Locus tag: Dmel_CG16944
See related: AllianceGenome:FB:FBgn0003360
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A/A-T; A/A-T/sesB; ADP/ATP translocase; ADT2; anon-WO02059370.55; ANT; ANT1; CG16944; dANT; Dmel\CG16944; dSLC25A4; EM12; Hmr; jive; l(1)9Ed; l(1)9Fa; l(1)DC701; l(1)EM31; l(1)G0126; l(1)G0247; l(1)G0386; l(1)S12; orangi; S12; ses B; sesb; SesB; SESB
Summary: Enables ATP:ADP antiporter activity. Involved in several processes, including determination of adult lifespan; intracellular calcium ion homeostasis; and muscle cell cellular homeostasis. Located in mitochondrial inner membrane. Is expressed in several structures, including adult head; adult heart; adult main segment of Malpighian tubule; adult midgut; and gonad. Used to study epilepsy and mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to human SLC25A4 (solute carrier family 25 member 4); SLC25A5 (solute carrier family 25 member 5); and SLC25A6 (solute carrier family 25 member 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 9E10-9F1; 1-33 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (10780893..10786958, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (10674926..10680991, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dcp-1 promotes autophagy by negatively regulating SesB and ATP levels.
Title: The Drosophila effector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesB.
The in vivo role of the sesB (ANT1) gene in cytosolic and mitochondrial Ca2+ signaling, was characterized.
Title: Mislocalization of mitochondria and compromised renal function and oxidative stress resistance in Drosophila SesB mutants.
Overexpression of the adenine nucleotide translocase encoded by the stress-sensitive B gene in Drosophila mitochondria increases proton conductance, and underexpression decreases it, even when the carrier is fully inhibited using carboxyatractylate
Title: The basal proton conductance of mitochondria depends on adenine nucleotide translocase content.
sesB(org) mutation reduces biochemically assayed ANT activity, suggest a model in which a continuous mitochondrial ANT-dependent supply of ATP is required to sustain NDK-dependent activation of presynaptic dynamin during normal range of synaptic activity
Title: A temperature-sensitive allele of Drosophila sesB reveals acute functions for the mitochondrial adenine nucleotide translocase in synaptic transmission and dynamin regulation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP:ADP antiporter activity	IEA Inferred from Electronic Annotation more info
enables ATP:ADP antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in action potential	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial ADP transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial ATP transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ATP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: stress-sensitive B

Names: ADP,ATP carrier protein; CG16944-PA; CG16944-PB; CG16944-PC; CG16944-PD; CG16944-PE; Stress-sensitive B; adenine nuclear translocase; adenine nucleotide translocase; drosophila ANT; lethal(1)9Ed; sesB-PA; sesB-PB; sesB-PC; sesB-PD; sesB-PE; stress sensitive B; stress-sensitive

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

10780893..10786958 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167247.2 → NP_727449.1 stress-sensitive B, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727449.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V491, P91614, Q0KHU3, Q26254, Q26365, Q53XG6, Q8IRA0, Q95S30, Q9VZ70

UniProtKB/TrEMBL

D1Z385

Related

FBpp0073280

Conserved Domains (2) summary

PTZ00169
Location:23 → 312

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:19 → 116

Mito_carr; Mitochondrial carrier protein
NM_001298161.1 → NP_001285090.1 stress-sensitive B, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285090.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JB48

Conserved Domains (1) summary

PTZ00169
Location:10 → 299

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
NM_078554.3 → NP_511109.1 stress-sensitive B, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511109.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JB48

Related

FBpp0073277

Conserved Domains (1) summary

PTZ00169
Location:10 → 299

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
NM_167246.2 → NP_727448.1 stress-sensitive B, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727448.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V491, P91614, Q0KHU3, Q26254, Q26365, Q53XG6, Q8IRA0, Q95S30, Q9VZ70

UniProtKB/TrEMBL

D1Z385

Related

FBpp0073278

Conserved Domains (2) summary

PTZ00169
Location:23 → 312

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:19 → 116

Mito_carr; Mitochondrial carrier protein
NM_167248.2 → NP_727450.1 stress-sensitive B, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727450.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JB48

Related

FBpp0073279

Conserved Domains (1) summary

PTZ00169
Location:10 → 299

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional