Wnt5 Wnt oncogene analog 5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Wnt5provided by FlyBase
Official Full Name: Wnt oncogene analog 5provided by FlyBase
Primary source: FLYBASE:FBgn0010194
Locus tag: Dmel_CG6407
See related: AllianceGenome:FB:FBgn0010194
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO03040301.228; CG6407; Dm DWnt3/5; Dm-3; Dmel\CG6407; Dwnt-3; DWnt-3; DWnt-3/5; Dwnt-5; DWnt-5; Dwnt3; DWnt3; Dwnt3/5; DWnt3/5; Dwnt5; DWnt5; Wnt; Wnt-3; wnt3; Wnt3; Wnt3/5; wnt5; WNT5
Summary: Enables receptor ligand activity. Involved in several processes, including determination of muscle attachment site; neuron projection morphogenesis; and positive regulation of cell projection organization. Located in dendrite and extracellular region. Is expressed in several structures, including A1-7 lateral transverse muscle cell; head segment; neuromere; neuron projection bundle; and ventral thoracic disc primordium. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 1. Orthologous to human WNT5A (Wnt family member 5A) and WNT5B (Wnt family member 5B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 17B6-17C1; 1-60 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (18501401..18505405, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (18395434..18399438, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that the final patterning of the fly olfactory map is the result of an interplay between olfactory receptor neurons axons and projection neuron dendrites, wherein converging pre- and postsynaptic processes contribute key Wnt5 signaling components, allowing Wnt5 to orient the rotation of nascent synapses through a planar cell polarity mechanism.
Title: Interplay between axonal Wnt5-Vang and dendritic Wnt5-Drl/Ryk signaling controls glomerular patterning in the Drosophila antennal lobe.
The pool of ADP-ribosylated Axin, which is degraded under basal conditions, increases immediately following Wnt stimulation in both Drosophila and human cells.
Title: Wnt pathway activation by ADP-ribosylation.
Wnt5 promotes dendrite termination on the periphery of sternites through the Ryk receptor family kinase Derailed (Drl) and the Rho GTPase guanine nucleotide exchange factor Trio in C4da neurons
Title: Adult Drosophila sensory neurons specify dendritic territories independently of dendritic contacts through the Wnt5-Drl signaling pathway.
Wnt5 is required for projection neurons dendrites migration and targeting in the developing antennal lobe.
Title: Wnt5 and drl/ryk gradients pattern the Drosophila olfactory dendritic map.
WNT5 interacts with doughnut and derailed to mediate muscle attachment site selection
Title: WNT5 interacts with the Ryk receptors doughnut and derailed to mediate muscle attachment site selection in Drosophila melanogaster.
Wnt5 is broadly expressed in the developing brain and regulates axonal development of mushroom body neurons.
Title: The Wnt5/planar cell polarity pathway regulates axonal development of the Drosophila mushroom body neuron.
Derailed protein (Drl) and derailed protein-2 (Drl-2) play opposing roles in Wnt5 signaling during olfactory system development, depending upon the type of cells in which they are expressed.
Title: Differentially expressed Drl and Drl-2 play opposing roles in Wnt5 signaling during Drosophila olfactory system development.
Src family kinases play novel roles in WNT5/Derailed-mediated signaling
Title: Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system.
Wnt5 regulates the growth of the Drosophila neuromuscular junction (NMJ) by signaling through the Derailed receptor.
Title: Derailed regulates development of the Drosophila neuromuscular junction.
The wnt5 as an anterograde signal that is expressed by olfactory axons and demonstrate a previously unappreciated, yet powerful, role for glia in patterning the Drosophila olfactory map.
Title: Antagonistic roles of Wnt5 and the Drl receptor in patterning the Drosophila antennal lobe.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemorepulsion of axon	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chemorepulsion of axon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of muscle attachment site	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of axon extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info