dome domeless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: domeprovided by FlyBase
Official Full Name: domelessprovided by FlyBase
Primary source: FLYBASE:FBgn0043903
Locus tag: Dmel_CG14226
See related: AllianceGenome:FB:FBgn0043903
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 142932_at; anon-18DEb; CG14226; CT33841; Dmel\CG14226; Dom; Dome; DOME; Domeless; domeMESO; l(1)G0217; l(1)G0218; l(1)G0264; l(1)G0282; l(1)G0321; l(1)G0367; l(1)G0405; l(1)G0441; l(1)G0468; mom; vsp
Summary: Enables several functions, including SOCS family protein binding activity; STAT family protein binding activity; and protein heterodimerization activity. Involved in several processes, including border follicle cell migration; cell surface receptor signaling pathway; and digestive tract development. Located in apical plasma membrane. Is expressed in several structures, including Kenyon cell; adult brain; follicle cell; gut section; and mushroom body. Used to study viral infectious disease. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 73 and autosomal recessive nonsyndromic deafness 84A. Orthologous to human PTPRQ (protein tyrosine phosphatase receptor type Q). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 18D13-18E1; 1-64 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19676061..19683518, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19570094..19577551, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Domeless receptor loss in fat body tissue reverts insulin resistance induced by a high-sugar diet in Drosophila melanogaster.
Title: Domeless receptor loss in fat body tissue reverts insulin resistance induced by a high-sugar diet in Drosophila melanogaster.
MASK is a positive regulator of Domeless dimerisation and protein levels.
Title: A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability.
The authors that the cytokine receptor homolog Dome, acting downstream of the niche-derived ligand Upd, directly binds to the microtubule-binding protein Eb1 to regulate spindle orientation in Drosophila male germline stem cells (GSCs).
Title: Cytokine receptor-Eb1 interaction couples cell polarity and fate during asymmetric cell division.
ectopic expression of Wdp inhibits JAK/STAT signaling activity. Importantly, we show that Wdp interacts with the receptor Domeless (Dome), and promotes its internalization for subsequent lysosomal degradation
Title: Windpipe controls Drosophila intestinal homeostasis by regulating JAK/STAT pathway via promoting receptor endocytosis and lysosomal degradation.
Drosophila epithelia lacking Hrs and Stam, accumulate Dome in endosomes.
Title: ESCRT-0 is not required for ectopic Notch activation and tumor suppression in Drosophila.
Awd mutant clones in the main-body follicle cells exhibited significant overaccumulation of Dome, confirming that Awd is a negative regulator of Dome expression.
Title: Awd, the homolog of metastasis suppressor gene Nm23, regulates Drosophila epithelial cell invasion.
ligand-independent dimerisation of the JAK/STAT receptor DOME confers cells with competence to activate the pathway prior to ligand reception
Title: Novel level of signalling control in the JAK/STAT pathway revealed by in situ visualisation of protein-protein interaction during Drosophila development.
Data indicate that Domeless is an essential receptor molecule for Upd and JAK/STAT signaling during oogenesis.
Title: The Drosophila cytokine receptor Domeless controls border cell migration and epithelial polarization during oogenesis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables SOCS family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables STAT family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytokine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in blastoderm segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to Gram-negative bacterium	HMP more info	PubMed
involved_in determination of digestive tract left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hindgut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: domeless

Names: CG14226-PA; dome; dome receptor; dome-PA; master of marelle; verstopft

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

19676061..19683518 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078688.3 → NP_523412.1 domeless [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523412.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VWE0

Related

FBpp0074525

Conserved Domains (2) summary

cd00063
Location:633 → 732

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:541 → 621

fn3; Fibronectin type III domain