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    Pepck1 Phosphoenolpyruvate carboxykinase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37131, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pepck1provided by FlyBase
    Official Full Name
    Phosphoenolpyruvate carboxykinase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0003067
    Locus tag
    Dmel_CG17725
    See related
    AllianceGenome:FB:FBgn0003067
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    143299_at; CG10924; CG17725; Dmel\CG17725; dPEPCK; Dromel_CG17725_FBtr0086701_pepck_mORF; pepck; Pepck; PEPCK; pepck1; PEPCK1
    Summary
    Predicted to enable manganese ion binding activity and phosphoenolpyruvate carboxykinase (GTP) activity. Involved in several processes, including gluconeogenesis; glycerol biosynthetic process; and triglyceride biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including Malpighian tubule primordium; adult head; amnioserosa; anlage in statu nascendi; and epidermis. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to several human genes including PCK1 (phosphoenolpyruvate carboxykinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pepck1 in Genome Data Viewer
    Location:
    55D3-55D3; 2-86 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18536767..18539416)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14424272..14426921)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphoenolpyruvate carboxykinase 2 Neighboring gene long non-coding RNA:CR46271 Neighboring gene uncharacterized protein Neighboring gene Rad, Gem/Kir family member 2 Neighboring gene Guanine nucleotide exchange factor in mesoderm Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide and deduced amino acid sequence of the phosphoenolpyruvate carboxykinase (GTP) from Drosophila melanogaster. Gundelfinger ED, et al. Nucleic Acids Res, 1987 Aug 25. PMID 3114718, Free PMC Article
    2. Isoforms of cyclic AMP response element binding proteins in Drosophila S2 cells. Poels J, et al. Biochem Biophys Res Commun, 2004 Jul 23. PMID 15219829
    3. Glucosylceramide synthase in the fat body controls energy metabolism in Drosophila. Kohyama-Koganeya A, et al. J Lipid Res, 2011 Jul. PMID 21550991, Free PMC Article
    4. Nutrigenomic Effects of White Rice and Brown Rice on the Pathogenesis of Metabolic Disorders in a Fruit Fly Model. Saka SO, et al. Molecules, 2023 Jan 5. PMID 36677591, Free PMC Article
    5. Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster. Wagner AE, et al. Oncotarget, 2015 Oct 13. PMID 26375250, Free PMC Article

    See all (144) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoenolpyruvate carboxykinase (GTP) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoenolpyruvate carboxykinase (GTP) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoenolpyruvate carboxykinase (GTP) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to glucose stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycerol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerol biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxaloacetate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in propionate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to lipid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in trehalose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    phosphoenolpyruvate carboxykinase 1
    Names
    CG17725-PA
    Pepck1-PA
    Phosphoenolpyruvate-carboxykinase
    phosphoenol pyruvate carboxykinase
    phosphoenol-pyruvate carboxykinase
    phosphoenolpyruvate carboxy kinase
    phosphoenolpyruvate carboxykinase
    NP_523784.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18536767..18539416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079060.3 → NP_523784.2  phosphoenolpyruvate carboxykinase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523784.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZB97, P20007, Q53YF8, Q9V8J0
      Related
      FBpp0085880
      Conserved Domains (1) summary
      pfam00821
      Location:54 → 644
      PEPCK; Phosphoenolpyruvate carboxykinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20007.2 P20007

    Gene LinkOut

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