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    T48 Transcript 48 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43235, updated on 9-Dec-2024

    Summary

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    Official Symbol
    T48provided by FlyBase
    Official Full Name
    Transcript 48provided by FlyBase
    Primary source
    FLYBASE:FBgn0004359
    Locus tag
    Dmel_CG5507
    See related
    AllianceGenome:FB:FBgn0004359
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    48; anon-97D; CG5507; Dmel\CG5507; t48; Ubx-t48
    Summary
    Involved in ventral furrow formation. Located in apical plasma membrane. Is expressed in several structures, including embryonic segment anterior compartment and mesoderm anlage. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See T48 in Genome Data Viewer
    Location:
    97D5-97D7; 3-92 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26881734..26910997)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22707456..22736719)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene male sterile (3) K81 Neighboring gene uncharacterized protein Neighboring gene rough Neighboring gene Ets at 97D Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targets of homeotic gene regulation in Drosophila. White RA, et al. J Cell Sci Suppl, 1992. PMID 1363662
    2. Regulation of spatiotemporal limits of developmental gene expression via enhancer grammar. Keller SH, et al. Proc Natl Acad Sci U S A, 2020 Jun 30. PMID 32541043, Free PMC Article
    3. Drosophila Fog/Cta and T48 pathways have overlapping and distinct contributions to mesoderm invagination. Horo U, et al. Mol Biol Cell, 2024 May 1. PMID 38536475, Free PMC Article
    4. The Genetic Basis of Natural Variation in Drosophila (Diptera: Drosophilidae) Virgin Egg Retention. Akhund-Zade J, et al. J Insect Sci, 2017 Jan. PMID 28042107, Free PMC Article
    5. Targets of homeotic gene control in Drosophila. Gould AP, et al. Nature, 1990 Nov 22. PMID 1979146

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila Fog/Cta and T48 pathways have overlapping and distinct contributions to mesoderm invagination.
      Title: Drosophila Fog/Cta and T48 pathways have overlapping and distinct contributions to mesoderm invagination.
    2. Both genes are expressed and required for mesoderm invagination in the fruit fly Drosophila melanogaster but do not appear during mesoderm ingression of the midge Chironomus riparius.
      Title: Folded gastrulation and T48 drive the evolution of coordinated mesoderm internalization in flies.
    3. identified a Twist target, T48, which acts with G protein signaling to orchestrate shape changes in the embryo; with G protein signaling, T48 recruits adherens junctions & RhoGEF2 to sites of apical constriction, ensuring changes in cell shape
      Title: Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in ventral furrow formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ventral furrow formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcript 48
    Names
    '48' transcript
    CG5507-PA
    CG5507-PB
    T48-PA
    T48-PB
    transcript-48

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26881734..26910997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276070.1 → NP_001262999.1  transcript 48, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262999.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24548, Q9VBA5
      Conserved Domains (1) summary
      cd00064
      Location:96 → 145
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

    2. NM_079798.3 → NP_524522.2  transcript 48, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524522.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24548, Q9VBA5
      Related
      FBpp0084437
      Conserved Domains (1) summary
      cd00064
      Location:96 → 145
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24548 Q24548
    Q9VBA5 Q9VBA5

    Gene LinkOut

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