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    Arf6 ADP ribosylation factor 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36699, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Arf6provided by FlyBase
    Official Full Name
    ADP ribosylation factor 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0013750
    Locus tag
    Dmel_CG8156
    See related
    AllianceGenome:FB:FBgn0013750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AFR51F; Arf3; ARF3; arf51f; arf51F; Arf51f; Arf51F; arf6; ARF6; ARFIII; CG8156; d-Arf6; dArf6; dARFIII; Dm Arf51F; Dmel\CG8156; EP(2)2612; LD12493; P40946
    Summary
    Enables enzyme activator activity. Involved in several processes, including behavioral response to ethanol; male meiosis cytokinesis; and myoblast fusion. Acts upstream of with a positive effect on imaginal disc-derived wing morphogenesis. Located in cleavage furrow; cytosol; and endosome. Colocalizes with adherens junction. Is expressed in several structures, including circulatory system primordium; embryonic/larval midgut primordium; ganglia; gut section; and head. Used to study alcohol use disorder and candidiasis. Orthologous to human ARF6 (ARF GTPase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Arf6 in Genome Data Viewer
    Location:
    51F6-51F6; 2-74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15322501..15325490)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11210006..11212995)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Xeroderma pigmentosum, complementation group C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. W::Neo: a novel dual-selection marker for high efficiency gene targeting in Drosophila. Zhou W, et al. PLoS One, 2012. PMID 22348139, Free PMC Article
    2. Characterization of class II and class III ADP-ribosylation factor genes and proteins in Drosophila melanogaster. Lee FJ, et al. J Biol Chem, 1994 Aug 26. PMID 8063793
    3. Target-selected mutant screen by TILLING in Drosophila. Winkler S, et al. Genome Res, 2005 May. PMID 15867432, Free PMC Article
    4. S6 Kinase Reflects and Regulates Ethanol-Induced Sedation. Acevedo SF, et al. J Neurosci, 2015 Nov 18. PMID 26586826, Free PMC Article
    5. IKKepsilon: a kinase at the intersection of signaling and membrane traffic. Gould GW. Sci Signal, 2011 Jun 14. PMID 21673314

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arf6 determines tissue architecture by stabilizing intercellular adhesion.
      Title: Arf6 determines tissue architecture by stabilizing intercellular adhesion.
    2. EGFR/ARF6 regulation of Hh signaling stimulates oncogenic Ras tumor overgrowth in Drosophila.
      Title: EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth.
    3. We show that Arf6 functions in the adult nervous system to control ethanol-induced behavior.
      Title: Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B.
    4. Cindr-mediated regulation of Arf6 is a widely used mechanism in emerging epithelia.
      Title: Role for a Cindr-Arf6 axis in patterning emerging epithelia.
    5. ARF6 promotes rapid recycling of endosomal membrane stores during spermatocyte cytokinesis, which is critical for rapid cleavage furrow ingression.
      Title: Spermatocyte cytokinesis requires rapid membrane addition mediated by ARF6 on central spindle recycling endosomes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male meiosis cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to alcohol IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ADP ribosylation factor 6
    Names
    ADP ribosylation factor 51F
    ADP ribosylation factor III
    ADP ribosylation factor at 51F
    Arf6-PA
    Arf6-PB
    Arf6-PC
    Arf6-PD
    Arf6-PE
    CG8156-PA
    CG8156-PB
    CG8156-PC
    CG8156-PD
    CG8156-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15322501..15325490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166090.2 → NP_725454.1  ADP ribosylation factor 6, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725454.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZH7, P40946, Q0E966, Q9V7B0
      Related
      FBpp0086507
      Conserved Domains (1) summary
      cl38936
      Location:1 → 174
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_166089.2 → NP_725453.1  ADP ribosylation factor 6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725453.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZH7, P40946, Q0E966, Q9V7B0
      Related
      FBpp0086509
      Conserved Domains (1) summary
      cl38936
      Location:1 → 174
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_079027.3 → NP_523751.2  ADP ribosylation factor 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523751.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZH7, P40946, Q0E966, Q9V7B0
      Related
      FBpp0086510
      Conserved Domains (1) summary
      cl38936
      Location:1 → 174
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_166088.2 → NP_725452.1  ADP ribosylation factor 6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725452.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZH7, P40946, Q0E966, Q9V7B0
      Related
      FBpp0086508
      Conserved Domains (1) summary
      cl38936
      Location:1 → 174
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. NM_166091.2 → NP_725455.1  ADP ribosylation factor 6, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725455.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZH7, P40946, Q0E966, Q9V7B0
      Related
      FBpp0086511
      Conserved Domains (1) summary
      cl38936
      Location:1 → 174
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40946.3 P40946

    Gene LinkOut

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