Ass Argininosuccinate synthase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Assprovided by FlyBase
Official Full Name: Argininosuccinate synthaseprovided by FlyBase
Primary source: FLYBASE:FBgn0026565
Locus tag: Dmel_CG1315
See related: AllianceGenome:FB:FBgn0026565
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS00004.14; CG1315; Dmel\CG1315
Summary: Predicted to enable argininosuccinate synthase activity. Predicted to be involved in L-arginine biosynthetic process; argininosuccinate metabolic process; and urea cycle. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in citrullinemia; classic citrullinemia; hepatocellular carcinoma; and melanoma. Orthologous to human ASS1 (argininosuccinate synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 84A1-84A1; 3-48 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (6642262..6644434, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (2467984..2470156, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1722 (e-PCR)
- UniSTS:51415

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables argininosuccinate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables argininosuccinate synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-arginine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-arginine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in argininosuccinate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in urea cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: argininosuccinate synthase

Names: Ass-PA; Ass-PB; CG1315-PA; CG1315-PB; argininosuccinate synthase-like

NP_001262324.1

EC 6.3.4.5

NP_649674.1

EC 6.3.4.5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

6642262..6644434 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275395.1 → NP_001262324.1 argininosuccinate synthase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262324.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0B4KFC7, C0HDN4, O97069, Q9VI41

Conserved Domains (1) summary

cd01999
Location:6 → 401

Argininosuccinate_Synthase; Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In ...
NM_141417.3 → NP_649674.1 argininosuccinate synthase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649674.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0B4KFC7, C0HDN4, O97069, Q9VI41

Related

FBpp0081197

Conserved Domains (1) summary

cd01999
Location:6 → 401

Argininosuccinate_Synthase; Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In ...