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    DCTN5-p25 Dynactin 5, p25 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34873, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DCTN5-p25provided by FlyBase
    Official Full Name
    Dynactin 5, p25 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040228
    Locus tag
    Dmel_CG10846
    See related
    AllianceGenome:FB:FBgn0040228
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS00929.1; br2; C4; CG10846; DCTN5; Dmel\CG10846; DS00929.1; dyn-p25; l(2)35Bf; l(2)br2; p25; P25
    Summary
    Involved in retrograde axonal transport and spermatogenesis. Predicted to be part of dynactin complex. Is expressed in adult head. Orthologous to human DCTN5 (dynactin subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DCTN5-p25 in Genome Data Viewer
    Location:
    35B8-35B8; 2-50 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15005733..15006607)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15005733..15006607)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45331 Neighboring gene moladietz Neighboring gene Ankrd49 Neighboring gene Negative Cofactor 2beta Neighboring gene tRNA-histidine guanylyltransferase Neighboring gene RNA guanine-7 methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in retrograde axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dynactin 5, p25 subunit
    Names
    CG10846-PA
    DCTN5-p25-PA
    Dynactin5 p25
    dynactin 5
    dynactin subunit p-25
    dynactin, p25 subunit
    dynactin-subunit-p25
    lethal 2 in the black-reduced region
    lethal group C4
    lethal(2)35Bf

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15005733..15006607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165097.4 → NP_723893.1  dynactin 5, p25 subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723893.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NHE4, Q9VJQ6
      Related
      FBpp0080255
      Conserved Domains (1) summary
      cd03359
      Location:13 → 178
      LbH_Dynactin_5; Dynactin 5 (or subunit p25); Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NHE4 Q9NHE4
    Q9VJQ6 Q9VJQ6

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