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    dtn detonator [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31555, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dtnprovided by FlyBase
    Official Full Name
    detonatorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262730
    Locus tag
    Dmel_CG14446
    See related
    AllianceGenome:FB:FBgn0262730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14446; CG14446 CES; Dmel\CG14446; lincRNA.S8753; MRE2
    Summary
    Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 99. Orthologous to several human genes including TMEM132A (transmembrane protein 132A); TMEM132B (transmembrane protein 132B); and TMEM132C (transmembrane protein 132C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dtn in Genome Data Viewer
    Location:
    5E1-5E1; 1-16 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6225647..6236218)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6119680..6130251)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ER GDP-fucose transporter Neighboring gene spaghetti squash Neighboring gene uncharacterized protein Neighboring gene Rabconnectin-3A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster. Chon C, et al. PLoS One, 2021. PMID 33444382, Free PMC Article
    2. Drosophila Dosage Compensation Loci Associate with a Boundary-Forming Insulator Complex. Kaye EG, et al. Mol Cell Biol, 2017 Nov 1. PMID 28784719, Free PMC Article
    3. Cell-Surface Proteomic Profiling in the Fly Brain Uncovers Wiring Regulators. Li J, et al. Cell, 2020 Jan 23. PMID 31955847, Free PMC Article
    4. Neuronal expression in Drosophila of an evolutionarily conserved metallophosphodiesterase reveals pleiotropic roles in longevity and odorant response. Gupta K, et al. PLoS Genet, 2023 Sep. PMID 37733787, Free PMC Article
    5. Identification and expression analysis of putative mRNA-like non-coding RNA in Drosophila. Inagaki S, et al. Genes Cells, 2005 Dec. PMID 16324153

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster.
      Title: Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    detonator
    Names
    CG14446-PB
    CG14446-PC
    CG14446-PD
    CG14446-PE
    dtn-PB
    dtn-PC
    dtn-PD
    dtn-PE
    mRNA-like ncRNA in embryogenesis 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6225647..6236218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258618.2 → NP_001245547.1  detonator, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245547.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W427
      Conserved Domains (4) summary
      pfam15705
      Location:18 → 170
      TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
      pfam15706
      Location:881 → 984
      TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
      pfam16070
      Location:440 → 795
      TMEM132; Transmembrane protein family 132
      cl02708
      Location:623 → 676
      Big_2; Bacterial Ig-like domain (group 2)

    2. NM_001298003.1 → NP_001284932.1  detonator, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284932.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JDW6
      Conserved Domains (4) summary
      pfam15705
      Location:18 → 170
      TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
      pfam15706
      Location:881 → 984
      TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
      pfam16070
      Location:440 → 795
      TMEM132; Transmembrane protein family 132
      cl02708
      Location:623 → 676
      Big_2; Bacterial Ig-like domain (group 2)

    3. NM_001298004.1 → NP_001284933.1  detonator, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284933.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JEB0
      Conserved Domains (4) summary
      pfam15705
      Location:18 → 170
      TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
      pfam15706
      Location:881 → 984
      TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
      pfam16070
      Location:440 → 795
      TMEM132; Transmembrane protein family 132
      cl02708
      Location:623 → 676
      Big_2; Bacterial Ig-like domain (group 2)

    4. NM_132072.4 → NP_572300.2  detonator, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572300.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W427
      Conserved Domains (4) summary
      pfam15705
      Location:18 → 170
      TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
      pfam15706
      Location:881 → 984
      TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
      pfam16070
      Location:440 → 795
      TMEM132; Transmembrane protein family 132
      cl02708
      Location:623 → 676
      Big_2; Bacterial Ig-like domain (group 2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W427 Q9W427
    X2JDW6 X2JDW6
    X2JEB0 X2JEB0

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