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    mldr mulder [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31568, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mldrprovided by FlyBase
    Official Full Name
    mulderprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029858
    Locus tag
    Dmel_CG15896
    See related
    AllianceGenome:FB:FBgn0029858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15896; Dmel\CG15896; MRPP3; PRORP
    Summary
    Predicted to enable ribonuclease P activity. Involved in mitochondrial tRNA processing. Located in mitochondrion. Part of mitochondrial ribonuclease P complex. Is expressed in organism. Used to study combined oxidative phosphorylation deficiency 54. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 54. Orthologous to human PRORP (protein only RNase P catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mldr in Genome Data Viewer
    Location:
    5E5-5E6; 1-16 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6291303..6294177)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6185336..6188210)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Topoisomerase 3beta Neighboring gene wuho Neighboring gene Regulatory particle triple-A ATPase 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduction of Drosophila Mitochondrial RNase P in Skeletal and Heart Muscle Causes Muscle Degeneration, Cardiomyopathy, and Heart Arrhythmia. Saoji M, et al. Front Cell Dev Biol, 2022. PMID 35663400, Free PMC Article
    2. Loss of Individual Mitochondrial Ribonuclease P Complex Proteins Differentially Affects Mitochondrial tRNA Processing In Vivo. Saoji M, et al. Int J Mol Sci, 2021 Jun 4. PMID 34199774, Free PMC Article
    3. Dysregulated mitochondrial and cytosolic tRNA m1A methylation in Alzheimer's disease. Shafik AM, et al. Hum Mol Genet, 2022 May 19. PMID 34897434, Free PMC Article
    4. Loss of the mitochondrial protein-only ribonuclease P complex causes aberrant tRNA processing and lethality in Drosophila. Sen A, et al. Nucleic Acids Res, 2016 Jul 27. PMID 27131785, Free PMC Article
    5. A Genetic Screen for Genes That Impact Peroxisomes in Drosophila Identifies Candidate Genes for Human Disease. Graves HK, et al. G3 (Bethesda), 2020 Jan 7. PMID 31767637, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ribonuclease P activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonuclease P activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial tRNA 5'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA 5'-leader removal IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial ribonuclease P complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mulder
    Names
    CG15896-PA
    CG15896-PB
    mldr-PA
    mldr-PB
    NP_001245549.1
    NP_572309.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6291303..6294177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258620.2 → NP_001245549.1  mulder, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245549.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5U1E0, Q8SYK6, Q9W413
      Conserved Domains (1) summary
      pfam16953
      Location:288 → 525
      PRORP; Protein-only RNase P

    2. NM_132081.4 → NP_572309.2  mulder, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572309.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5U1E0, Q8SYK6, Q9W413
      Related
      FBpp0070863
      Conserved Domains (1) summary
      pfam16953
      Location:288 → 525
      PRORP; Protein-only RNase P
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U1E0 Q5U1E0
    Q8SYK6 Q8SYK6
    Q9W413 Q9W413
    Q9W413.1

    Gene LinkOut

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