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    pira pirate [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32229, updated on 9-Dec-2024

    Summary

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    Official Symbol
    piraprovided by FlyBase
    Official Full Name
    pirateprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030420
    Locus tag
    Dmel_CG12717
    See related
    AllianceGenome:FB:FBgn0030420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12717; Dmel\CG12717
    Summary
    Predicted to enable SUMO-specific endopeptidase activity and deSUMOylase activity. Involved in central nervous system projection neuron axonogenesis and dendritic spine morphogenesis. Located in cytoplasm and nucleus. Orthologous to human SENP7 (SUMO specific peptidase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pira in Genome Data Viewer
    Location:
    11B16-11B16; 1-39 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12760642..12763611, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12654675..12657644, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44619 Neighboring gene VSR interacting RNA Neighboring gene PAICS bifunctional enzyme Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene uncharacterized protein Neighboring gene Phosphodiesterase 9 Neighboring gene Neprilysin 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The SUMO protease Verloren regulates dendrite and axon targeting in olfactory projection neurons. Berdnik D, et al. J Neurosci, 2012 Jun 13. PMID 22699913, Free PMC Article
    2. piRNA-mediated gene regulation and adaptation to sex-specific transposon expression in D. melanogaster male germline. Chen P, et al. Genes Dev, 2021 Jun. PMID 33985970, Free PMC Article
    3. SUMO regulates the activity of Smoothened and Costal-2 in Drosophila Hedgehog signaling. Zhang J, et al. Sci Rep, 2017 Feb 14. PMID 28195188, Free PMC Article
    4. What Are the Functional Roles of Piwi Proteins and piRNAs in Insects? Santos D, et al. Insects, 2023 Feb 14. PMID 36835756, Free PMC Article
    5. Streamlined discovery of cross-linked chromatin complexes and associated histone modifications by mass spectrometry. Zee BM, et al. Proc Natl Acad Sci U S A, 2016 Feb 16. PMID 26831069, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SUMO-specific endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deSUMOylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in central nervous system projection neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein desumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pirate
    Names
    CG12717-PA
    CG12717-PB
    pira-PA
    pira-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12760642..12763611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298238.1 → NP_001285167.1  pirate, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285167.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29QU9, Q9VYJ5
      Conserved Domains (2) summary
      pfam05466
      Location:122 → 319
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl23802
      Location:396 → 585
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    2. NM_132599.3 → NP_572827.1  pirate, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572827.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29QU9, Q9VYJ5
      Related
      FBpp0073537
      Conserved Domains (2) summary
      pfam05466
      Location:122 → 319
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl23802
      Location:396 → 585
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYJ5 Q9VYJ5

    Gene LinkOut

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