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    Brms1 BRMS1 transcriptional repressor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32243, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Brms1provided by FlyBase
    Official Full Name
    BRMS1 transcriptional repressorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030434
    Locus tag
    Dmel_CG4400
    See related
    AllianceGenome:FB:FBgn0030434
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BRMS1L; CG4400; dBrms1; Dmel\CG4400
    Summary
    Predicted to enable histone deacetylase binding activity. Involved in positive regulation of transcription by RNA polymerase II. Part of Sin3-type complex. Is expressed in ring gland. Orthologous to human BRMS1L (BRMS1 like transcriptional repressor) and BRMS1 (BRMS1 transcriptional repressor and anoikis regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Brms1 in Genome Data Viewer
    Location:
    11D1-11D1; 1-41 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12907986..12909622, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12802019..12803655, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L49 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45625

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of Social Stress and Neural Degeneration by Activity-Regulated Genes and Epigenetic Mechanisms in Dopaminergic Neurons. Kent C, et al. Mol Neurobiol, 2020 Nov. PMID 32748368, Free PMC Article
    2. dBrms1 acts as a positive regulator of notch signaling in Drosophila wing. Zhang Q, et al. J Genet Genomics, 2014 Jun 20. PMID 24976121
    3. Enabling cell-type-specific behavioral epigenetics in Drosophila: a modified high-yield INTACT method reveals the impact of social environment on the epigenetic landscape in dopaminergic neurons. Agrawal P, et al. BMC Biol, 2019 Apr 10. PMID 30967153, Free PMC Article
    4. Systematic Analysis of SIN3 Histone Modifying Complex Components During Development. Barnes VL, et al. Sci Rep, 2018 Nov 19. PMID 30451916, Free PMC Article
    5. The Drosophila ortholog of breast cancer metastasis suppressor gene, dBrms1, is critical for developmental timing through regulating ecdysone signaling. Song S, et al. Dev Biol, 2013 Aug 15. PMID 23707898

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. provide important insights into the biological function of dBrms1 in regulating Notch signaling.
      Title: dBrms1 acts as a positive regulator of notch signaling in Drosophila wing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Sin3-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BRMS1 transcriptional repressor
    Names
    BRMS1
    BRMS1 ortholog
    Brms1-PA
    CG4400-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12907986..12909622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132612.2 → NP_572840.1  BRMS1 transcriptional repressor [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572840.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYI2
      Related
      FBpp0073526
      Conserved Domains (1) summary
      pfam08598
      Location:59 → 176
      Sds3; Sds3-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYI2 Q9VYI2

    Gene LinkOut

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