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    ENGase Endo-beta-N-acetylglucosaminidase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32726, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ENGaseprovided by FlyBase
    Official Full Name
    Endo-beta-N-acetylglucosaminidaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030839
    Locus tag
    Dmel_CG5613
    See related
    AllianceGenome:FB:FBgn0030839
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5613; Dmel\CG5613
    Summary
    Enables myosin binding activity. Predicted to be involved in N-glycan processing. Predicted to be located in cytoplasm. Orthologous to human ENGASE (endo-beta-N-acetylglucosaminidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ENGase in Genome Data Viewer
    Location:
    16A5-16A5; 1-57 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17423591..17428735)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17317624..17322768)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene BarH1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene presidents-cup Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytosolic O-GlcNAcylation and PNG1 maintain Drosophila gut homeostasis by regulating proliferation and apoptosis. Na HJ, et al. PLoS Genet, 2022 Mar. PMID 35294432, Free PMC Article
    2. A multiplexable TALE-based binary expression system for in vivo cellular interaction studies. Toegel M, et al. Nat Commun, 2017 Nov 21. PMID 29162808, Free PMC Article
    3. Rare recombination events generate sequence diversity among balancer chromosomes in Drosophila melanogaster. Miller DE, et al. Proc Natl Acad Sci U S A, 2016 Mar 8. PMID 26903656, Free PMC Article
    4. Manual curation and phylogenetic analysis of chitinase family genes in the Asian citrus psyllid, Diaphorina citri. Shippy TD, et al. GigaByte, 2022. PMID 36824529, Free PMC Article
    5. Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation. Gelbart ME, et al. Nat Struct Mol Biol, 2009 Aug. PMID 19648925, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables myosin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Endo-beta-N-acetylglucosaminidase
    Names
    CG5613-PA
    CG5613-PB
    ENGase-PA
    ENGase-PB
    NP_573215.1
    NP_788923.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17423591..17428735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132987.2 → NP_573215.1  Endo-beta-N-acetylglucosaminidase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573215.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T8V2, Q9VX51
      Related
      FBpp0074205
      Conserved Domains (1) summary
      cd06547
      Location:144 → 476
      GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...

    2. NM_176750.2 → NP_788923.1  Endo-beta-N-acetylglucosaminidase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788923.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H5V8D6, Q86B46
      Related
      FBpp0074206
      Conserved Domains (1) summary
      cd06547
      Location:81 → 413
      GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86B46 Q86B46
    Q8T8V2 Q8T8V2
    Q9VX51 Q9VX51

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