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    wry weary [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33361, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wryprovided by FlyBase
    Official Full Name
    wearyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051665
    Locus tag
    Dmel_CG31665
    See related
    AllianceGenome:FB:FBgn0051665
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12704; CG15621; CG31665; CT35769; Dmel\CG31665
    Summary
    Enables Notch binding activity and receptor ligand activity. Involved in Notch signaling pathway and heart process. Located in cell surface. Is expressed in several structures, including adult head; embryonic central brain neurons; ganglia; larval nervous system; and larval ventral midline glial cell. Used to study dilated cardiomyopathy. Orthologous to human DNER (delta/notch like EGF repeat containing). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wry in Genome Data Viewer
    Location:
    22B3-22B4; 2-3 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1836538..1858550)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1836538..1858550)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mir-2280 stem loop Neighboring gene calcutta cup Neighboring gene long non-coding RNA:CR44073 Neighboring gene long non-coding RNA:CR44074 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44075 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand. Kim IM, et al. Circ Res, 2010 Apr 16. PMID 20203305, Free PMC Article
    2. Mechanisms of Non-canonical Signaling in Health and Disease: Diversity to Take Therapy up a Notch? Alfred V, et al. Adv Exp Med Biol, 2018. PMID 30030827
    3. Drosophila tools and assays for the study of human diseases. Ugur B, et al. Dis Model Mech, 2016 Mar. PMID 26935102, Free PMC Article
    4. Human Diseases Associated with Notch Signalling: Lessons from Drosophila melanogaster. Megaly M, et al. Front Biosci (Landmark Ed), 2024 Jun 25. PMID 38940046
    5. Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer's Disease. Hsieh YC, et al. Cell Rep, 2019 Oct 8. PMID 31597093, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identify CG31665/Wry as a previously unknown Notch ligand in Drosophila that when deleted causes cardiomyopathy.
      Title: Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Notch binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Notch binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heart process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    weary
    Names
    CG31665-PB
    CG31665-PC
    CG31665-PD
    fibropellin
    wry-PB
    wry-PC
    wry-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1836538..1858550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164443.4 → NP_722737.3  weary, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722737.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQ47
      Conserved Domains (2) summary
      cd00054
      Location:857 → 891
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:784 → 813
      EGF; EGF-like domain

    2. NM_205889.4 → NP_995611.2  weary, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995611.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KU08
      Conserved Domains (2) summary
      cd00054
      Location:856 → 890
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:783 → 812
      EGF; EGF-like domain

    3. NM_001258913.2 → NP_001245842.1  weary, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245842.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEN9
      Conserved Domains (2) summary
      cd00054
      Location:856 → 890
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:783 → 812
      EGF; EGF-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NEN9 M9NEN9
    Q7KU08 Q7KU08
    Q8MYS3 Q8MYS3
    Q9VQ47 Q9VQ47

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